NCHU Course Outline
Course Name (中) 高等化學生物學專論(8027)
(Eng.) Advanced Chemical Biology
Offering Dept Graduate Institute of Biotechnology
Course Type Elective Credits 4 Teacher 中研院教師
Department Graduate Institute of BiotechnologyPh.D Language English Semester 2024-FALL
Course Description Chemical Biology is the science of applying chemical principles and tools to understand and alter biological systems.
The goal of this course is to teach students fundamental knowledge in chemical biology and molecular biophysics, and also to understand the basics of bioorganic chemistry and bioanalytical chemistry.
Prerequisites
self-directed learning in the course N
Relevance of Course Objectives and Core Learning Outcomes(%) Teaching and Assessment Methods for Course Objectives
Course Objectives Competency Indicators Ratio(%) Teaching Methods Assessment Methods
知識整合與歸納能力的養成
3.Capable of searching and retrieving data.
4.Capable of planning and designing laboratory experiments.
50
50
Lecturing
Discussion
Quiz
Oral Presentation
Course Content and Homework/Schedule/Tests Schedule
Week Course Content
Week 1 What is chemical biology?
Nucleic acid structure and synthesis
No class (Mid-Autumn Festival)
DNA sequencing and DNA mimetics
RNA: RNA interference
Ribozymes and aptamers
Carbohydrates: structure
Carbohydrates: biosynthesis and function
Carbohydrates: applications
Carbohydrates: chemical synthesis
Introduction to lipids and membranes
Carbohydrates: chemical synthesis
Lipid structure
Protein synthesis and folding
Protein degradation and quality control
Protein misfolding and neurodegeneration
Producing proteins and peptides
Chromatography and electrophoresis
Protein extraction, subcellular fractionation, centrifugation
Antibody technologies
Humanized antibody
Structural Biology
Labeling with fluorophores and biotin
Fluorescent proteins and FRET
Basics of Fluorescence Microscopy
Super-resolution Optical Microscopy
Bioorthogonal chemistry; Active site probe
Mass spec: instrumentation
Mass spec of proteins
Mass spec and protein quantification
Post-translational modifications
Biotech job market and industry outlook
Week 2
Week 3
Week 4
Week 5
Week 6
Week 7
Week 8
Week 9
Week 10
Week 11
Week 12
Week 13
Week 14
Week 15
Week 16
Week 17
Week 18
Evaluation
期中、期末測驗以及課堂報告
Textbook & other References
"Essentials of Glycobiology" 2nd Edition, by Varki A., Cummings R.D., Esko
J.D., et al., editors.Cold Spring Harbor (NY): Cold Spring Harbor Laboratory
Press; 2009.
"Biochemistry" 7yh ed., by J. M. Berg, J. L. Tymocko and L. Stryer. Freeman, New York, 2012.
Teaching Aids & Teacher's Website
教師自製講義
Office Hours
未限定時間
Sustainable Development Goals, SDGs
 include experience courses:N
Please respect the intellectual property rights and use the materials legally.Please repsect gender equality.
Update Date, year/month/day:None Printed Date, year/month/day:2024 / 10 / 07
The second-hand book website:http://www.myub.com.tw/