NCHU Course Outline
Course Name (中) 微生物遺傳與基因體特論(一)(6079)
(Eng.) Topics in Microbial Genetics and Genomics(I)
Offering Dept Graduate Institute of Genomics and Bioinformatics
Course Type Elective Credits 2 Teacher YING-TSONG CHEN
Department Graduate Institute of Genomics and Bioinformatics/Graduate Language 中/英文 Semester 2024-FALL
Course Description Microbial genomics is the study of the molecular organization of the genome, their content, and the genes they encode. DNA can be sequenced using different methods. Microbial genome can be sequenced using whole-genome shotgun sequencing in which random genomic DNA fragments are sequenced and then assembled by computer to give the complete genome. Analyzing bacterial genomes can be the foundations in investigating bacterial physiology, their genome structures, molecular evolution, antimicrobial resistance, pathogenesis and more. It will also help in preparing new vaccines and new drugs for the treatment of infections. Both experimental genomics and bioinformatic tools for microbial genomics will be introduced in the course.
Prerequisites
self-directed learning in the course Y
Relevance of Course Objectives and Core Learning Outcomes(%) Teaching and Assessment Methods for Course Objectives
Course Objectives Competency Indicators Ratio(%) Teaching Methods Assessment Methods
Introducing the critical topics in the development of genomics in bacteria and studying microbiome



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4.
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50
topic Discussion/Production
Discussion
Lecturing
Practicum
Oral Presentation
Internship
Written Presentation
Attendance
Assignment
Study Outcome
Quiz
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Course Content and Homework/Schedule/Tests Schedule
Week Course Content
Week 1 Introduction to the course
Week 2 DNA and RNA
Week 3 Determing DNA sequence - Sanger sequencing
Week 4 Determing DNA sequence - NGS
Week 5 Determing DNA sequence - Single molecular sequencing
Week 6 The concept of whole genome shotgun
Week 7 Bioinformatics basics - Linux
Week 8 Bioinformatics basics - Linux
Week 9 Bioinformatics basics - Linux
Week 10 Bioinformatics - Handling sequencing data
Week 11 Bioinformatics - Introducing assembly pipelines
Week 12 Bioinformatics - Annotation
Week 13 Bioinformatics - analyzing bacterial antimicrobial resistance and Virulence factors
Week 14 Bioinformatics - cgMLST and molecular phylogeny
Week 15 Bioinformatics - Comparative genomics of Bacteria
Week 16 Bioinformatics - Molecular Evolution of Bacterial Genomes
Week 17 self-directed learning
Week 18 self-directed learning
Evaluation
專題研究、實作、報告與討論
Textbook & other References
Molecular Genetics of Bacteria 4th. Ed. Snyder & Peters, ASM Press 2012
Other selected paper and review articles




Teaching Aids & Teacher's Website
Teaching materials will be avaliable in eCampus




Office Hours
週一下午1:30-2:30

Sustainable Development Goals, SDGs
include experience courses:N
Please respect the intellectual property rights and use the materials legally.Please repsect gender equality.
Update Date, year/month/day:2024/07/28 16:49:28 Printed Date, year/month/day:2024 / 10 / 11
The second-hand book website:http://www.myub.com.tw/