NCHU Course Outline

Course Name	(中) 維生素與單碳代謝導論(5214)
	(Eng.) Introduction of Vitamins in One Carbon Metabolism
Offering Dept	Department of Food Science and Biotechnology
Course Type	Elective	Credits	2	Teacher	蔣恩沛
Department	Department of Food Science and Biotechnology/Graduate	Language	English	Semester	2024-FALL
Course Description	This course will introduce the basic concepts of one-carbon metabolism and the functions of vitamin coenzymes involved in the main reactions I our body. The goal of the course is to introduce the nutritional biochemistry in OCM in detail to students who are conducting research in related fields, and to deeply explore the latest research on OCM in recent years. It includes the main vitamin cofactors of enzymes in OCM, cellular absorption, vitamin uptake and retention, assimilation and dissimilation of folic acid, folic acid antagonists, regulation of folate dependent transmethylation, transsulfuration and homocysteine remethylation, genetic variability and dietary effects on OCM, cellular and genetic patterns on metabolic kinetics in human diseases and therapies
Prerequisites				self-directed learning in the course	Y

Relevance of Course Objectives and Core Learning Outcomes(%)			Teaching and Assessment Methods for Course Objectives
Course Objectives	Competency Indicators	Ratio(%)	Teaching Methods	Assessment Methods
to introduce the basic concepts of one-carbon metabolism and the functions of vitamin coenzymes involved in the main reactions I our body. The goal of the course is to introduce the nutritional biochemistry in OCM in detail to students who are conducting research in related fields, and to deeply explore the latest research on OCM in recent years. It includes the main vitamin cofactors of enzymes in OCM, cellular absorption, vitamin uptake and retention, assimilation and dissimilation of folic acid, folic acid antagonists, regulation of folate dependent transmethylation, transsulfuration and homocysteine remethylation, genetic variability and dietary effects on OCM, cellular and genetic patterns on metabolic kinetics in human diseases and therapies. 介紹單碳代謝基本概念以及參與其中主要反應之維生素輔酶之功能。課程之目標為對進行相關領域研究之同學詳盡介紹單碳代謝中之營養生化、並深入探討近年來生素與單碳代謝的最新研究。將包括單碳代謝中之酵素的維生素輔因子、細胞對於葉酸的吸收、滯留、同化及異化作用、葉酸拮抗藥物、轉甲基、轉硫與同半胱胺酸再甲基作用之調控、基因的變異性與飲食對單碳代謝的影響、細胞模式與遺傳性老鼠的模式、單碳代謝與疾病。			Lecturing Discussion topic Discussion/Production	Other Oral Presentation Written Presentation Attendance Assignment
Course Content and Homework/Schedule/Tests Schedule
Week Course Content Week 1 Introduction Week 2 Overview Week 3 Nutrient-Genome Interactions in 1C metabolism in Human Health. Lecture Week 4 Nutrient-Genome Interactions in 1C metabolism in Human Health. Case Study: MTHFR in LEUKEMIA Week 5 Nutrient-Genome Interactions in 1C metabolism in Human Health. Case Study: MTHFR and MTX efficacy Week 6 Drug-Genome Interactions in 1C metabolism. Case Study: Drug and gene interactions, (DMARDs MTX, SSZ, Pred, CsA, LEF) Week 7 Drug-Genome Interactions in 1C metabolism. Case Study: NSADIs Week 8 Enzymes in 1C Metabolism & Their Interactions with Cofactors. Lecture Week 9 Partitioning in 1C Metabolism and Their Interactions with Cofactors. Lecture Week 10 Partitioning in 1C Metabolism and Their Interactions with Cofactors. Case: Study: SHMT I. II. MTHFS Week 11 Metabolites in 1C metabolism Lecture: glycine, formate, choline, etc Week 12 Metabolites in 1C Metabolism. Case Study: GCS, GLY, and what's next? Week 13 Folate and Folic Acid in Cancer. Lecture Week 14 Folate and Folic Acid in Cancer. Case Study: GNMT I, II, III, and what's next? Week 15 Dietary factors that affect 1C Metabolism-Sugar, HF, CR, KD, If, and the gene-nutrient interactions with GNMT Week 16 Factors affect 1C Metabolism-Energy Expenditure. Case Study: Aerobic vs. Anerobic excercise, HF vs. CR Week 17 Dietary factors affect 1C Metabolism-phytochemicals. Case: SFN and PQQ Week 18 Dietary factors affect 1C Metabolism-food factors. Case Study: AS (SFN and PQQ) 1C Metabolism in Human Diseases. Lecture: Statistical Analyses for case control, RCT. Case Study: AJM, JN, Gut, CCR, WJG 1C Metabolism in Human Diseases. Lecture: B6 vitamers, Human Study Design 1C Metabolism in Human Diseases. Case Study: AR1, AR2, JPET, AJCN, and what's the next? 1C Metabolism in Human Diseases. Lecture and case Study: inflammation, PF, Sarcopenia? 1C Metabolism in Human Diseases. Lecture and case Study: type 1 & type 2 DB, Metformin and Actros. Term paper and homework discussions (I) 1C Metabolism in microbes? Term paper and homework discussions (II) Term paper and homework discussions (III)
Evaluation
1. Oral presentation 2. Written report (term-paper or proposal) 3. Class participation and discussions
Textbook & other References
Course materials 1. Lecture printouts. 2. Handbook of Vitamins ISBN: 0-8247-0428-2, Third Edition (Clinical Nutrition in Health and Disease) by Robert B. Rucker (Author), John W. Suttie (Author), Donald B. McCormick (Author) 3. Advanced Nutrition and Human Metabolism. 5th ed. Seattle, WA. Nutritional biochemistry by Tom Brody. 2nd. Ed 4. Food and Nutrition in Translational Medicine Workshop from Stover PJ 5. Selected recent papers from the field.
Teaching Aids & Teacher's Website
Course materials 1. Lecture printouts. 2. Handbook of Vitamins ISBN: 0-8247-0428-2, Third Edition (Clinical Nutrition in Health and Disease) by Robert B. Rucker (Author), John W. Suttie (Author), Donald B. McCormick (Author) 3. Advanced Nutrition and Human Metabolism. 5th ed. Seattle, WA. Nutritional biochemistry by Tom Brody. 2nd. Ed 4. Food and Nutrition in Translational Medicine Workshop from Stover PJ 5. Selected recent papers from the field.
Office Hours
by appointment (另與教師個別約時間)
Sustainable Development Goals, SDGs
include experience courses：N

Please respect the intellectual property rights and use the materials legally.Please repsect gender equality.
Update Date, year/month/day：None	Printed Date, year/month/day：2024 / 11 / 21
The second-hand book website：http://www.myub.com.tw/