| Relevance of Course Objectives and Core Learning Outcomes(%) |
Teaching and Assessment Methods for Course Objectives |
| Course Objectives |
Competency Indicators |
Ratio(%) |
Teaching Methods |
Assessment Methods |
| Special Topics in One Carbon Metabolism |
|
|
| Discussion |
| Lecturing |
| topic Discussion/Production |
|
| Study Outcome |
| Written Presentation |
| Attendance |
| Oral Presentation |
|
| Course Content and Homework/Schedule/Tests Schedule |
| Week |
Course Content |
| Week 1 |
Introduction |
| Week 2 |
Overview |
| Week 3 |
Nutrient-Genome Interactions in 1C metabolism in Human Health. Case Study: Regulation of Folate-Mediated One-Carbon Metabolism by Methylenetetrahydrofolate Reductase (MTHFR). |
| Week 4 |
Nutrient-Genome Interactions in 1C metabolism in Human Health. Case Study: Regulation of Folate-Mediated One-Carbon Metabolism by Glycine N-Methyltransferase (GNMT) |
| Week 5 |
Drug-Genome Interactions in 1C metabolism. Case Study: Drug and gene interactions. Case Study: Regulation of Folate-Mediated One-Carbon Metabolism by DMARDs
Term paper and homework discussions 1 |
| Week 6 |
Drug impacts on 1C metabolism. Case Study: Regulation of Folate-Mediated One-Carbon Metabolism by Biologics (Jaki, anti-TNF, anti-IL6)
Term paper and homework discussions 2 |
| Week 7 |
Partitioning in 1C Metabolism and Their Interactions with Cofactors. Case Study: non-nutritive sweeteners
Enzymes in 1C Metabolism & Their Interactions with Cofactors. Term paper and homework discussions 3 |
| Week 8 |
Partitioning in 1C Metabolism and Their Interactions with Cofactors. Case Study: Regulation of aerobic exercise and endurance resistant training on 1C metabolism
Term paper and homework discussions 4 |
| Week 9 |
Partitioning in 1C Metabolism and Their Interactions with Cofactors. Case Study: Regulation of prebiotics probiotics and postbiotics on 1C metabolism
Term paper and homework discussions 5 |
| Week 10 |
Folate and Folic Acid in Cancer. Case Study: GNMT I, II, III, and what’s next?
Term paper and homework discussions 6 |
| Week 11 |
Dietary factors that affect 1C Metabolism, and the gene-nutrient interactions. Tracing Metabolic Fate of Mitochondrial Glycine Cleavage System Derived Formate In Vitro and In Vivo. Factors affect 1C Metabolism-Energy Expenditure (ketogenic diet, intermittent fasting and caloric restriction)
Term paper and homework discussions 7 |
| Week 12 |
1C Metabolism in Human Diseases. Lecture: Statistical Analyses for Human Study Design (case control, RCT). Case Study: AJM, JN, Gut, CCR, WJG
Term paper and homework discussions 8 |
| Week 13 |
1C Metabolism in Human Diseases. Case Study: Vitamin B6 metabolism during inflammation
Term paper and homework discussions 9
|
| Week 14 |
1C Metabolism in Human Diseases. Lecture and case Study:1C in inflammation
Term paper and homework discussions 10 |
| Week 15 |
1C Metabolism in Human Diseases. Lecture and case Study: diabetes and anti diabetic medications
Term paper and homework discussions 11 |
| Week 16 |
1C Metabolism in Human Diseases. Lecture and case Study: One-Carbon Metabolism during aging
Term paper and homework discussions 12 |
| Week 17 |
|
| Week 18 |
|
|
| Evaluation |
| In class participation and discussions (25%); Term paper (25%); The final grade will also be assessed based on overall research performance, including experimental results, conference abstract submissions, poster and/or oral competitions, research innovation contests, patent applications, and SCI paper publications (50%) |
| Textbook & other References |
1. Lecture printouts.
2. Handbook of Vitamins ISBN: 0-8247-0428-2, Third Edition (Clinical Nutrition in Health and Disease) by Robert B. Rucker (Author), John W. Suttie (Author), Donald B. McCormick (Author)
3. Advanced Nutrition and Human Metabolism. 5th ed. Seattle, WA. Nutritional biochemistry by Tom Brody. 2nd. Ed
4. Food and Nutrition in Translational Medicine Workshop from Stover PJ
5. Selected recent papers in the field. |
| Teaching Aids & Teacher's Website |
Lecture printouts
https://sites.google.com/email.nchu.edu.tw/chiang-lab-2021/publish?authuser=0 |
| Office Hours |
| Monday Noon-1 pm |
| Sustainable Development Goals, SDGs(Link URL) |
| include experience courses：N |
|