NCHU Course Outline

Course Name	(中) 分子免疫學文獻探討(一)(8108)
	(Eng.) Review of Literature in Molecular Immunology (I)
Offering Dept	Department of Veterinary Medicine
Course Type	Elective	Credits	1	Teacher	CHI-YOUNG WANG ect.
Department	Department of Veterinary MedicinePh.D	Language	English	Semester	2024-FALL
Course Description	This class is to design as the journal club for the graduate students who are interested to acquire some advanced knowledge in the field of molecular immunology. Students can learn how to design, interpret, and complete a scientific research proposal after reading papers.
Prerequisites				self-directed learning in the course	N

Relevance of Course Objectives and Core Learning Outcomes(%)			Teaching and Assessment Methods for Course Objectives
Course Objectives	Competency Indicators	Ratio(%)	Teaching Methods	Assessment Methods
Establishment of the basic concept about the veterinary immunology for the graduate student. Understanding of the experiment techniques in the molecular immunology.			Discussion	Written Presentation Assignment
Course Content and Homework/Schedule/Tests Schedule
Week Course Content Week 1 Tropism, replication competence, and innate immune responses of the coronavirus SARS-CoV-2 in human respiratory tract and conjunctiva: an analysis in ex-vivo and in-vitro cultures. Lancet Respir Med. 2020 Jul;8(7):687-695. Week 2 METTL3 regulates viral m6A RNA modification and host cell innate immune responses during SARS-CoV-2 infection. Cell Rep. 2021 May 11;35(6):109091. Week 3 Targeting liquid-liquid phase separation of SARS-CoV-2 nucleocapsid protein promotes innate antiviral immunity by elevating MAVS activity. Nat Cell Biol. 2021 Jul;23(7):718-732. Week 4 Student Report I Week 5 Attenuating innate immunity and facilitating β-coronavirus infection by NSP1 of SARS-CoV-2 through specific redistributing hnRNP A2/B1 cellular localization. Signal Transduct Target Ther. 2021 Oct 26;6(1):371. Week 6 Influenza M2 protein regulates MAVS-mediated signaling pathway through interacting with MAVS and increasing ROS production. Autophagy. 2019 Jul;15(7):1163-1181. Week 7 RNF115 plays dual roles in innate antiviral responses by catalyzing distinct ubiquitination of MAVS and MITA. Nat Commun. 2020 Nov 2;11(1):5536. Week 8 The PB1 protein of influenza A virus inhibits the innate immune response by targeting MAVS for NBR1-mediated selective autophagic degradation. PLoS Pathog. 2021 Feb 12;17(2):e1009300. Week 9 Student Report II Week 10 Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense. Cell 2020 Apr 30;181(3):674-687.e13. Week 11 SARS-CoV-2 N protein promotes NLRP3 inflammasome activation to induce hyperinflammation. Nat Commun. 2021 Aug 2;12(1):4664. Week 12 Dengue Virus Serotype 2 and Its Non-Structural Proteins 2A and 2B Activate NLRP3 Inflammasome. Front Immunol. 2020 Mar 10;11:352. Week 13 STING promotes NLRP3 localization in ER and facilitates NLRP3 deubiquitination to activate the inflammasome upon HSV-1 infection. PLoS Pathog. 2020 Mar 18;16(3):e1008335. Week 14 Student Report III Week 15 Ebola virus glycoprotein stimulates IL-18-dependent natural killer cell responses. J Clin Invest. 2020 Jul 1;130(7):3936-3946. Week 16 RTP4 Is a Potent IFN-Inducible Anti-flavivirus Effector Engaged in a Host-Virus Arms Race in Bats and Other Mammals. Cell Host Microbe. 2020 Nov 11;28(5):712-723.e9. Week 17 MxA-independent inhibition of Hantaan virus replication induced by type I and type II interferon in vitro. Virus Res. 2007 Jul;127(1):100-5. Week 18 Final Discussion
Evaluation
The performance of the report and discission
Textbook & other References
Lancet Respir Med Cell Rep Nat Cell Biol Autophagy Cell PLoS Pathog J Clin Invest Cell Host Microbe Virus Res Front Immunol Nat Commun Signal Transduct Target Ther
Teaching Aids & Teacher's Website
Office Hours
Wed 4:00 PM-5:00 PM
Sustainable Development Goals, SDGs
include experience courses：N

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Update Date, year/month/day：None	Printed Date, year/month/day：2024 / 11 / 21
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