NCHU Course Outline

Course Name	(中) 動物病毒學文獻探討(二)(7165)
	(Eng.) Review of Literature in Animal Virology(II)
Offering Dept	Department of Veterinary Medicine
Course Type	Elective	Credits	1	Teacher	CHI-YOUNG WANG ect.
Department	Department of Veterinary Medicine/Graduate	Language	English	Semester	2024-FALL
Course Description	This class is to design as a open discussion for the graduate students who are interested to further acquire more knowledge in the field of molecular virology. Students can learn how to evaluate, interpret, and complete a scientific research proposal.
Prerequisites				self-directed learning in the course	N

Relevance of Course Objectives and Core Learning Outcomes(%)			Teaching and Assessment Methods for Course Objectives
Course Objectives	Competency Indicators	Ratio(%)	Teaching Methods	Assessment Methods
Establishment of the basic reading ability for the graduate student. Training of the scientific logic for the graduate student. Understanding of the experiment techniques in the molecular virology for the graduate student.			Discussion topic Discussion/Production	Oral Presentation Attendance
Course Content and Homework/Schedule/Tests Schedule
Week Course Content Week 1 Characterization of the DNA binding activity of structural protein VP1 from chicken anemia virus. BMC Veterinary Research 14:155. Week 2 Interferon-induced human MxA GTPase blocks nuclear import of Thogoto virus nucelocapsids. Proc. Natl. Acad. Sci. USA 96:2082-2086. Week 3 Inhibition of Borna disease virus replication by an endogenous bornavirus-like element in the ground squirrel genome. Proc. Natl. Acad. Sci. 36:13175-13180. Week 4 Student report:I Week 5 Importin alpha nuclear localization signal binding sites for STAT1, STAT2, and influenza A virus nucleoprotein. Journal of Biological Chemistry 278:28193-28200. Week 6 Entry of Scotophilus bat coronavirus-512 and severe acute respiratory syndrome coronavirus in human and multiple animal cells. Pathogens 8:259. Week 7 Infectious bronchitis virus regulates cellular stress granule signaling. Viruses 12:536. Week 8 In vivo siRNA delivery using JC virus-like particles decreases the expression of RANKL in rats. Molecular Therapy-Nucleic Acids 5:e298. Week 9 Student report:II Week 10 Characterization of the DNA binding properties of polyomavirus capsid proteins. Journal of Virology 67:6327-6331. Week 11 Functional analysis of the interferon-stimulated response element of porcine circovirus type 2 and its role during viral replication in vitro and in vivo. Virology Journal 9:152. Week 12 Encephalomyocarditid virus viroporin 2B activates NLRP3 inflammasome. Plos Pathogens 8:e1002857. Week 13 Cellular transcription factor SP1 recruits simian virus 40 capisd proteins to the viral package signal, ses. Journal of Virology 76:5915-5924. Week 14 Interaction of the replication proteins and the capsid protein of porcine circovirus type 1 and 2 with host proteins. Virology 386:122-131. Week 15 Student report:III Week 16 HIV-1 myristoylated Nef treatment of murine microglial cells activates inducible nitric oxide synthase, NO2 production and neurotoxic activity. Plos One 10:e0130189. Week 17 Efficient gene transfer using the human JC virus-like particle that inhibits human colon adenocarcinoma growth in anude mouse model. Gene Theray 17:1033-1041. Week 18 Final discussion
Evaluation
The performance of report and discussion
Textbook & other References
Journal of Virology Journal of General Virology Plos Pathogens Molecular therapy Pathogens Journal of Biological Chemistry Virology Plos One
Teaching Aids & Teacher's Website
Office Hours
Friday 4:00 PM-5:00 PM
Sustainable Development Goals, SDGs
include experience courses：N

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Update Date, year/month/day：None	Printed Date, year/month/day：2024 / 11 / 21
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