NCHU Course Outline
Course Name (中) 進階組織工程學(8050)
(Eng.) Advanced Tissue Engineering
Offering Dept Doctoral Program in Biotechnology Industrial Management and Innovation
Course Type Elective Credits 2 Teacher 田川陽一
Department Doctoral Program in Biotechnology Industrial Management and InnovationPh.D Language English Semester 2025-SPRING
Course Description Advanced Tissue engineering is a biomedical engineering discipline that uses a combination of cells, engineering, materials methods, and suitable biochemical and physicochemical factors to restore, maintain, improve, or replace different types of biological tissues. The course here will involve from the basic concepts of cellular physiology and molecular biology to transgenic mouse and stem cell that already become tools for regenerative medicine.(Syllabus, teaching materials and assessment methods are all in English,密集課程,集中上課。)
Prerequisites
self-directed learning in the course Y
Relevance of Course Objectives and Core Learning Outcomes(%) Teaching and Assessment Methods for Course Objectives
Course Objectives Competency Indicators Ratio(%) Teaching Methods Assessment Methods
Advanced Tissue engineering is the core for regenerative medicine, the course would like to bring the students to understand the basic concepts and related molecule tools.
Discussion
Lecturing
Written Presentation
Attendance
Assignment
Course Content and Homework/Schedule/Tests Schedule
Week Course Content
Week 1 Date Time Hour Content
17 April 1~4 p.m. 3 hours Introduction, Mammalian Tissues and Organs, especially focusing on Liver
18 April 1~4 p.m. 3 hours Mammalian cells cannot survive without adhesion, ’Cell Adhesion’.
21 April 1~4 p.m. 3 hours Molecular Biology for Tissue Engineering
22 April 1~4 p.m. 3 hours Artificial Organs and Tissues
23 April 1~4 p.m. 3 hours Viruses, Cell Fusion, DDS and Decellularization
24 April 1~4 p.m. 3 hours Developmental Biology such as Transgenic/Gene KO Animals
25 April 1~4 p.m. 3 hours ES/iPS cells, Clone Animals, Regenerative Medicine
19 May 1~4 p.m. 3 hours Bioethics, Biosafety, Biosecurity, Alternatives to Animal Testing
20 May 1~4 p.m. 3 hours Organ-on-a Chip, Organoids, MPS
21 May 1~4 p.m. 3 hours Tour of the Intestine Chip (Microfluidic Device System), etc
22 May 1~3 p.m. 2 hours* Exam*
*The exam will be held on May 22 from 1PM-3PM. A make-up exam will be offered at a later date for those who are unable to take the exam that day.
Week 2 Date Time Hour Content
17 April 1~4 p.m. 3 hours Introduction, Mammalian Tissues and Organs, especially focusing on Liver
18 April 1~4 p.m. 3 hours Mammalian cells cannot survive without adhesion, ’Cell Adhesion’.
21 April 1~4 p.m. 3 hours Molecular Biology for Tissue Engineering
22 April 1~4 p.m. 3 hours Artificial Organs and Tissues
23 April 1~4 p.m. 3 hours Viruses, Cell Fusion, DDS and Decellularization
24 April 1~4 p.m. 3 hours Developmental Biology such as Transgenic/Gene KO Animals
25 April 1~4 p.m. 3 hours ES/iPS cells, Clone Animals, Regenerative Medicine
19 May 1~4 p.m. 3 hours Bioethics, Biosafety, Biosecurity, Alternatives to Animal Testing
20 May 1~4 p.m. 3 hours Organ-on-a Chip, Organoids, MPS
21 May 1~4 p.m. 3 hours Tour of the Intestine Chip (Microfluidic Device System), etc
22 May 1~3 p.m. 2 hours* Exam*
*The exam will be held on May 22 from 1PM-3PM. A make-up exam will be offered at a later date for those who are unable to take the exam that day.
Week 3 Date Time Hour Content
17 April 1~4 p.m. 3 hours Introduction, Mammalian Tissues and Organs, especially focusing on Liver
18 April 1~4 p.m. 3 hours Mammalian cells cannot survive without adhesion, ’Cell Adhesion’.
21 April 1~4 p.m. 3 hours Molecular Biology for Tissue Engineering
22 April 1~4 p.m. 3 hours Artificial Organs and Tissues
23 April 1~4 p.m. 3 hours Viruses, Cell Fusion, DDS and Decellularization
24 April 1~4 p.m. 3 hours Developmental Biology such as Transgenic/Gene KO Animals
25 April 1~4 p.m. 3 hours ES/iPS cells, Clone Animals, Regenerative Medicine
19 May 1~4 p.m. 3 hours Bioethics, Biosafety, Biosecurity, Alternatives to Animal Testing
20 May 1~4 p.m. 3 hours Organ-on-a Chip, Organoids, MPS
21 May 1~4 p.m. 3 hours Tour of the Intestine Chip (Microfluidic Device System), etc
22 May 1~3 p.m. 2 hours* Exam*
*The exam will be held on May 22 from 1PM-3PM. A make-up exam will be offered at a later date for those who are unable to take the exam that day.
Week 4 Date Time Hour Content
17 April 1~4 p.m. 3 hours Introduction, Mammalian Tissues and Organs, especially focusing on Liver
18 April 1~4 p.m. 3 hours Mammalian cells cannot survive without adhesion, ’Cell Adhesion’.
21 April 1~4 p.m. 3 hours Molecular Biology for Tissue Engineering
22 April 1~4 p.m. 3 hours Artificial Organs and Tissues
23 April 1~4 p.m. 3 hours Viruses, Cell Fusion, DDS and Decellularization
24 April 1~4 p.m. 3 hours Developmental Biology such as Transgenic/Gene KO Animals
25 April 1~4 p.m. 3 hours ES/iPS cells, Clone Animals, Regenerative Medicine
19 May 1~4 p.m. 3 hours Bioethics, Biosafety, Biosecurity, Alternatives to Animal Testing
20 May 1~4 p.m. 3 hours Organ-on-a Chip, Organoids, MPS
21 May 1~4 p.m. 3 hours Tour of the Intestine Chip (Microfluidic Device System), etc
22 May 1~3 p.m. 2 hours* Exam*
*The exam will be held on May 22 from 1PM-3PM. A make-up exam will be offered at a later date for those who are unable to take the exam that day.
Week 5 Date Time Hour Content
17 April 1~4 p.m. 3 hours Introduction, Mammalian Tissues and Organs, especially focusing on Liver
18 April 1~4 p.m. 3 hours Mammalian cells cannot survive without adhesion, ’Cell Adhesion’.
21 April 1~4 p.m. 3 hours Molecular Biology for Tissue Engineering
22 April 1~4 p.m. 3 hours Artificial Organs and Tissues
23 April 1~4 p.m. 3 hours Viruses, Cell Fusion, DDS and Decellularization
24 April 1~4 p.m. 3 hours Developmental Biology such as Transgenic/Gene KO Animals
25 April 1~4 p.m. 3 hours ES/iPS cells, Clone Animals, Regenerative Medicine
19 May 1~4 p.m. 3 hours Bioethics, Biosafety, Biosecurity, Alternatives to Animal Testing
20 May 1~4 p.m. 3 hours Organ-on-a Chip, Organoids, MPS
21 May 1~4 p.m. 3 hours Tour of the Intestine Chip (Microfluidic Device System), etc
22 May 1~3 p.m. 2 hours* Exam*
*The exam will be held on May 22 from 1PM-3PM. A make-up exam will be offered at a later date for those who are unable to take the exam that day.
Week 6 Date Time Hour Content
17 April 1~4 p.m. 3 hours Introduction, Mammalian Tissues and Organs, especially focusing on Liver
18 April 1~4 p.m. 3 hours Mammalian cells cannot survive without adhesion, ’Cell Adhesion’.
21 April 1~4 p.m. 3 hours Molecular Biology for Tissue Engineering
22 April 1~4 p.m. 3 hours Artificial Organs and Tissues
23 April 1~4 p.m. 3 hours Viruses, Cell Fusion, DDS and Decellularization
24 April 1~4 p.m. 3 hours Developmental Biology such as Transgenic/Gene KO Animals
25 April 1~4 p.m. 3 hours ES/iPS cells, Clone Animals, Regenerative Medicine
19 May 1~4 p.m. 3 hours Bioethics, Biosafety, Biosecurity, Alternatives to Animal Testing
20 May 1~4 p.m. 3 hours Organ-on-a Chip, Organoids, MPS
21 May 1~4 p.m. 3 hours Tour of the Intestine Chip (Microfluidic Device System), etc
22 May 1~3 p.m. 2 hours* Exam*
*The exam will be held on May 22 from 1PM-3PM. A make-up exam will be offered at a later date for those who are unable to take the exam that day.
Week 7 Date Time Hour Content
17 April 1~4 p.m. 3 hours Introduction, Mammalian Tissues and Organs, especially focusing on Liver
18 April 1~4 p.m. 3 hours Mammalian cells cannot survive without adhesion, ’Cell Adhesion’.
21 April 1~4 p.m. 3 hours Molecular Biology for Tissue Engineering
22 April 1~4 p.m. 3 hours Artificial Organs and Tissues
23 April 1~4 p.m. 3 hours Viruses, Cell Fusion, DDS and Decellularization
24 April 1~4 p.m. 3 hours Developmental Biology such as Transgenic/Gene KO Animals
25 April 1~4 p.m. 3 hours ES/iPS cells, Clone Animals, Regenerative Medicine
19 May 1~4 p.m. 3 hours Bioethics, Biosafety, Biosecurity, Alternatives to Animal Testing
20 May 1~4 p.m. 3 hours Organ-on-a Chip, Organoids, MPS
21 May 1~4 p.m. 3 hours Tour of the Intestine Chip (Microfluidic Device System), etc
22 May 1~3 p.m. 2 hours* Exam*
*The exam will be held on May 22 from 1PM-3PM. A make-up exam will be offered at a later date for those who are unable to take the exam that day.
Week 8 Date Time Hour Content
17 April 1~4 p.m. 3 hours Introduction, Mammalian Tissues and Organs, especially focusing on Liver
18 April 1~4 p.m. 3 hours Mammalian cells cannot survive without adhesion, ’Cell Adhesion’.
21 April 1~4 p.m. 3 hours Molecular Biology for Tissue Engineering
22 April 1~4 p.m. 3 hours Artificial Organs and Tissues
23 April 1~4 p.m. 3 hours Viruses, Cell Fusion, DDS and Decellularization
24 April 1~4 p.m. 3 hours Developmental Biology such as Transgenic/Gene KO Animals
25 April 1~4 p.m. 3 hours ES/iPS cells, Clone Animals, Regenerative Medicine
19 May 1~4 p.m. 3 hours Bioethics, Biosafety, Biosecurity, Alternatives to Animal Testing
20 May 1~4 p.m. 3 hours Organ-on-a Chip, Organoids, MPS
21 May 1~4 p.m. 3 hours Tour of the Intestine Chip (Microfluidic Device System), etc
22 May 1~3 p.m. 2 hours* Exam*
*The exam will be held on May 22 from 1PM-3PM. A make-up exam will be offered at a later date for those who are unable to take the exam that day.
Week 9 Date Time Hour Content
17 April 1~4 p.m. 3 hours Introduction, Mammalian Tissues and Organs, especially focusing on Liver
18 April 1~4 p.m. 3 hours Mammalian cells cannot survive without adhesion, ’Cell Adhesion’.
21 April 1~4 p.m. 3 hours Molecular Biology for Tissue Engineering
22 April 1~4 p.m. 3 hours Artificial Organs and Tissues
23 April 1~4 p.m. 3 hours Viruses, Cell Fusion, DDS and Decellularization
24 April 1~4 p.m. 3 hours Developmental Biology such as Transgenic/Gene KO Animals
25 April 1~4 p.m. 3 hours ES/iPS cells, Clone Animals, Regenerative Medicine
19 May 1~4 p.m. 3 hours Bioethics, Biosafety, Biosecurity, Alternatives to Animal Testing
20 May 1~4 p.m. 3 hours Organ-on-a Chip, Organoids, MPS
21 May 1~4 p.m. 3 hours Tour of the Intestine Chip (Microfluidic Device System), etc
22 May 1~3 p.m. 2 hours* Exam*
*The exam will be held on May 22 from 1PM-3PM. A make-up exam will be offered at a later date for those who are unable to take the exam that day.
Week 10 Date Time Hour Content
17 April 1~4 p.m. 3 hours Introduction, Mammalian Tissues and Organs, especially focusing on Liver
18 April 1~4 p.m. 3 hours Mammalian cells cannot survive without adhesion, ’Cell Adhesion’.
21 April 1~4 p.m. 3 hours Molecular Biology for Tissue Engineering
22 April 1~4 p.m. 3 hours Artificial Organs and Tissues
23 April 1~4 p.m. 3 hours Viruses, Cell Fusion, DDS and Decellularization
24 April 1~4 p.m. 3 hours Developmental Biology such as Transgenic/Gene KO Animals
25 April 1~4 p.m. 3 hours ES/iPS cells, Clone Animals, Regenerative Medicine
19 May 1~4 p.m. 3 hours Bioethics, Biosafety, Biosecurity, Alternatives to Animal Testing
20 May 1~4 p.m. 3 hours Organ-on-a Chip, Organoids, MPS
21 May 1~4 p.m. 3 hours Tour of the Intestine Chip (Microfluidic Device System), etc
22 May 1~3 p.m. 2 hours* Exam*
*The exam will be held on May 22 from 1PM-3PM. A make-up exam will be offered at a later date for those who are unable to take the exam that day.
Week 11 Date Time Hour Content
17 April 1~4 p.m. 3 hours Introduction, Mammalian Tissues and Organs, especially focusing on Liver
18 April 1~4 p.m. 3 hours Mammalian cells cannot survive without adhesion, ’Cell Adhesion’.
21 April 1~4 p.m. 3 hours Molecular Biology for Tissue Engineering
22 April 1~4 p.m. 3 hours Artificial Organs and Tissues
23 April 1~4 p.m. 3 hours Viruses, Cell Fusion, DDS and Decellularization
24 April 1~4 p.m. 3 hours Developmental Biology such as Transgenic/Gene KO Animals
25 April 1~4 p.m. 3 hours ES/iPS cells, Clone Animals, Regenerative Medicine
19 May 1~4 p.m. 3 hours Bioethics, Biosafety, Biosecurity, Alternatives to Animal Testing
20 May 1~4 p.m. 3 hours Organ-on-a Chip, Organoids, MPS
21 May 1~4 p.m. 3 hours Tour of the Intestine Chip (Microfluidic Device System), etc
22 May 1~3 p.m. 2 hours* Exam*
*The exam will be held on May 22 from 1PM-3PM. A make-up exam will be offered at a later date for those who are unable to take the exam that day.
Week 12 Date Time Hour Content
17 April 1~4 p.m. 3 hours Introduction, Mammalian Tissues and Organs, especially focusing on Liver
18 April 1~4 p.m. 3 hours Mammalian cells cannot survive without adhesion, ’Cell Adhesion’.
21 April 1~4 p.m. 3 hours Molecular Biology for Tissue Engineering
22 April 1~4 p.m. 3 hours Artificial Organs and Tissues
23 April 1~4 p.m. 3 hours Viruses, Cell Fusion, DDS and Decellularization
24 April 1~4 p.m. 3 hours Developmental Biology such as Transgenic/Gene KO Animals
25 April 1~4 p.m. 3 hours ES/iPS cells, Clone Animals, Regenerative Medicine
19 May 1~4 p.m. 3 hours Bioethics, Biosafety, Biosecurity, Alternatives to Animal Testing
20 May 1~4 p.m. 3 hours Organ-on-a Chip, Organoids, MPS
21 May 1~4 p.m. 3 hours Tour of the Intestine Chip (Microfluidic Device System), etc
22 May 1~3 p.m. 2 hours* Exam*
*The exam will be held on May 22 from 1PM-3PM. A make-up exam will be offered at a later date for those who are unable to take the exam that day.
Week 13 Date Time Hour Content
17 April 1~4 p.m. 3 hours Introduction, Mammalian Tissues and Organs, especially focusing on Liver
18 April 1~4 p.m. 3 hours Mammalian cells cannot survive without adhesion, ’Cell Adhesion’.
21 April 1~4 p.m. 3 hours Molecular Biology for Tissue Engineering
22 April 1~4 p.m. 3 hours Artificial Organs and Tissues
23 April 1~4 p.m. 3 hours Viruses, Cell Fusion, DDS and Decellularization
24 April 1~4 p.m. 3 hours Developmental Biology such as Transgenic/Gene KO Animals
25 April 1~4 p.m. 3 hours ES/iPS cells, Clone Animals, Regenerative Medicine
19 May 1~4 p.m. 3 hours Bioethics, Biosafety, Biosecurity, Alternatives to Animal Testing
20 May 1~4 p.m. 3 hours Organ-on-a Chip, Organoids, MPS
21 May 1~4 p.m. 3 hours Tour of the Intestine Chip (Microfluidic Device System), etc
22 May 1~3 p.m. 2 hours* Exam*
*The exam will be held on May 22 from 1PM-3PM. A make-up exam will be offered at a later date for those who are unable to take the exam that day.
Week 14 Date Time Hour Content
17 April 1~4 p.m. 3 hours Introduction, Mammalian Tissues and Organs, especially focusing on Liver
18 April 1~4 p.m. 3 hours Mammalian cells cannot survive without adhesion, ’Cell Adhesion’.
21 April 1~4 p.m. 3 hours Molecular Biology for Tissue Engineering
22 April 1~4 p.m. 3 hours Artificial Organs and Tissues
23 April 1~4 p.m. 3 hours Viruses, Cell Fusion, DDS and Decellularization
24 April 1~4 p.m. 3 hours Developmental Biology such as Transgenic/Gene KO Animals
25 April 1~4 p.m. 3 hours ES/iPS cells, Clone Animals, Regenerative Medicine
19 May 1~4 p.m. 3 hours Bioethics, Biosafety, Biosecurity, Alternatives to Animal Testing
20 May 1~4 p.m. 3 hours Organ-on-a Chip, Organoids, MPS
21 May 1~4 p.m. 3 hours Tour of the Intestine Chip (Microfluidic Device System), etc
22 May 1~3 p.m. 2 hours* Exam*
*The exam will be held on May 22 from 1PM-3PM. A make-up exam will be offered at a later date for those who are unable to take the exam that day.
Week 15 Date Time Hour Content
17 April 1~4 p.m. 3 hours Introduction, Mammalian Tissues and Organs, especially focusing on Liver
18 April 1~4 p.m. 3 hours Mammalian cells cannot survive without adhesion, ’Cell Adhesion’.
21 April 1~4 p.m. 3 hours Molecular Biology for Tissue Engineering
22 April 1~4 p.m. 3 hours Artificial Organs and Tissues
23 April 1~4 p.m. 3 hours Viruses, Cell Fusion, DDS and Decellularization
24 April 1~4 p.m. 3 hours Developmental Biology such as Transgenic/Gene KO Animals
25 April 1~4 p.m. 3 hours ES/iPS cells, Clone Animals, Regenerative Medicine
19 May 1~4 p.m. 3 hours Bioethics, Biosafety, Biosecurity, Alternatives to Animal Testing
20 May 1~4 p.m. 3 hours Organ-on-a Chip, Organoids, MPS
21 May 1~4 p.m. 3 hours Tour of the Intestine Chip (Microfluidic Device System), etc
22 May 1~3 p.m. 2 hours* Exam*
*The exam will be held on May 22 from 1PM-3PM. A make-up exam will be offered at a later date for those who are unable to take the exam that day.
Week 16 Date Time Hour Content
17 April 1~4 p.m. 3 hours Introduction, Mammalian Tissues and Organs, especially focusing on Liver
18 April 1~4 p.m. 3 hours Mammalian cells cannot survive without adhesion, ’Cell Adhesion’.
21 April 1~4 p.m. 3 hours Molecular Biology for Tissue Engineering
22 April 1~4 p.m. 3 hours Artificial Organs and Tissues
23 April 1~4 p.m. 3 hours Viruses, Cell Fusion, DDS and Decellularization
24 April 1~4 p.m. 3 hours Developmental Biology such as Transgenic/Gene KO Animals
25 April 1~4 p.m. 3 hours ES/iPS cells, Clone Animals, Regenerative Medicine
19 May 1~4 p.m. 3 hours Bioethics, Biosafety, Biosecurity, Alternatives to Animal Testing
20 May 1~4 p.m. 3 hours Organ-on-a Chip, Organoids, MPS
21 May 1~4 p.m. 3 hours Tour of the Intestine Chip (Microfluidic Device System), etc
22 May 1~3 p.m. 2 hours* Exam*
*The exam will be held on May 22 from 1PM-3PM. A make-up exam will be offered at a later date for those who are unable to take the exam that day.
Week 17 Date Time Hour Content
17 April 1~4 p.m. 3 hours Introduction, Mammalian Tissues and Organs, especially focusing on Liver
18 April 1~4 p.m. 3 hours Mammalian cells cannot survive without adhesion, ’Cell Adhesion’.
21 April 1~4 p.m. 3 hours Molecular Biology for Tissue Engineering
22 April 1~4 p.m. 3 hours Artificial Organs and Tissues
23 April 1~4 p.m. 3 hours Viruses, Cell Fusion, DDS and Decellularization
24 April 1~4 p.m. 3 hours Developmental Biology such as Transgenic/Gene KO Animals
25 April 1~4 p.m. 3 hours ES/iPS cells, Clone Animals, Regenerative Medicine
19 May 1~4 p.m. 3 hours Bioethics, Biosafety, Biosecurity, Alternatives to Animal Testing
20 May 1~4 p.m. 3 hours Organ-on-a Chip, Organoids, MPS
21 May 1~4 p.m. 3 hours Tour of the Intestine Chip (Microfluidic Device System), etc
22 May 1~3 p.m. 2 hours* Exam*
*The exam will be held on May 22 from 1PM-3PM. A make-up exam will be offered at a later date for those who are unable to take the exam that day.
Week 18 Date Time Hour Content
17 April 1~4 p.m. 3 hours Introduction, Mammalian Tissues and Organs, especially focusing on Liver
18 April 1~4 p.m. 3 hours Mammalian cells cannot survive without adhesion, ’Cell Adhesion’.
21 April 1~4 p.m. 3 hours Molecular Biology for Tissue Engineering
22 April 1~4 p.m. 3 hours Artificial Organs and Tissues
23 April 1~4 p.m. 3 hours Viruses, Cell Fusion, DDS and Decellularization
24 April 1~4 p.m. 3 hours Developmental Biology such as Transgenic/Gene KO Animals
25 April 1~4 p.m. 3 hours ES/iPS cells, Clone Animals, Regenerative Medicine
19 May 1~4 p.m. 3 hours Bioethics, Biosafety, Biosecurity, Alternatives to Animal Testing
20 May 1~4 p.m. 3 hours Organ-on-a Chip, Organoids, MPS
21 May 1~4 p.m. 3 hours Tour of the Intestine Chip (Microfluidic Device System), etc
22 May 1~3 p.m. 2 hours* Exam*
*The exam will be held on May 22 from 1PM-3PM. A make-up exam will be offered at a later date for those who are unable to take the exam that day.
Evaluation
Interaction in the class 50%
Report 50%
Textbook & other References
Principles of Tissue Engineering (Robert Lanza, ‎Robert Langer, ‎Joseph P. Vacanti · 2020)
Teaching Aids & Teacher's Website
ilearning
Office Hours
By Appointment
Sustainable Development Goals, SDGs(Link URL)
08.Decent Work and Economic Growthinclude experience courses:N
Please respect the intellectual property rights and use the materials legally.Please respect gender equality.
Update Date, year/month/day:2025/02/17 09:59:13 Printed Date, year/month/day:2025 / 3 / 29
The second-hand book website:http://www.myub.com.tw/