NCHU Course Outline
Course Name (中) 結構與系統生物學(6245)
(Eng.) Structural Systems Biology
Offering Dept Department of Animal Science
Course Type Elective Credits 3 Teacher Kun-Yi Hsin
Department Department of Animal Science/Graduate Language English Semester 2025-SPRING
Course Description This course aims to teach students the state-of-the-art methodologies and algorithms in Structural Biology and Systems Biology. In addition, the course includes the hands-on case studies allowing students to practice skills taught in the lectures. Students will be taught knowledge in protein structure and its functionality and will be capable of composing and analyzing complex molecular pathway. This course will lead students to thoughtful perspective in elaborating biological phenomena observed.
Prerequisites
self-directed learning in the course Y
Relevance of Course Objectives and Core Learning Outcomes(%) Teaching and Assessment Methods for Course Objectives
Course Objectives Competency Indicators Ratio(%) Teaching Methods Assessment Methods
to train students understanding the molecular structure and its functions as well as the molecular interactions.
Lecturing
Discussion
Exercises
topic Discussion/Production
Other
Internship
Attendance
Written Presentation
Course Content and Homework/Schedule/Tests Schedule
Week Course Content
Week 1 Introduction to Structural Biology.
Week 2 Introduction to Systems Biology.
Week 3 Molecular structure.
Week 4 Structure determination, refinement, and validation.
Week 5 Data management in the modern structural biology.
Week 6 Data management in the modern systems biology.
Week 7 Molecular interaction.
Week 8 Protein-ligand interaction.
Week 9 Protein-protein interaction.
Week 10 Modelling for molecular structure.
Week 11 Modelling for molecular interaction.
Week 12 Analysis of Structure-Activity Relationship.
Week 13 Dynamic systems biology modelling and simulation.
Week 14 Molecular dynamics simulation.
Week 15 Virtual high-throughput screening.
Week 16 Application in biomedicine.
Week 17 Self-study I: Practice of molecular pathway curation.
Week 18 Self-study II: Survey of open-type resource for macromolecules.
Evaluation
participation rate, homeworks
Textbook & other References
1. Foundations of Systems Biology (Kitano)
2. Systems Biology (Klipp)
3. Virtual Screening (Mannhold Ed.)
4. Bioinformatics for Systems Biology (Krawetz)
Teaching Aids & Teacher's Website

Office Hours
Working hour or by appointment.
Sustainable Development Goals, SDGs
include experience courses:N
Please respect the intellectual property rights and use the materials legally.Please repsect gender equality.
Update Date, year/month/day:None Printed Date, year/month/day:2025 / 1 / 22
The second-hand book website:http://www.myub.com.tw/