NCHU Course Outline

Course Name	(中) 維生素與單碳代謝特論(5167)
	(Eng.) Special Topics in One Carbon Metabolism
Offering Dept	Department of Food Science and Biotechnology
Course Type	Elective	Credits	2	Teacher	蔣恩沛
Department	Department of Food Science and Biotechnology/Graduate	Language	English	Semester	2025-SPRING
Course Description	Special Topics in One Carbon Metabolism
Prerequisites				self-directed learning in the course	Y

Relevance of Course Objectives and Core Learning Outcomes(%)			Teaching and Assessment Methods for Course Objectives
Course Objectives	Competency Indicators	Ratio(%)	Teaching Methods	Assessment Methods
Special Topics in One Carbon Metabolism			Discussion Lecturing topic Discussion/Production	Study Outcome Written Presentation Attendance Oral Presentation
Course Content and Homework/Schedule/Tests Schedule
Week Course Content Week 1 Introduction Week 2 Overview Week 3 Nutrient-Genome Interactions in 1C metabolism in Human Health. Lecture Week 4 Nutrient-Genome Interactions in 1C metabolism in Human Health. Case Study Week 5 Drug-Genome Interactions in 1C metabolism. Case Study: Drug and gene interactions (DMARDs) Week 6 Drug impacts on 1C metabolism. Case Study: Biologics (Jaki, anti-TNF, anti-IL6) Enzymes in 1C Metabolism & Their Interactions with Cofactors. Lecture Week 7 Partitioning in 1C Metabolism and Their Interactions with Cofactors. Lecture Week 8 Partitioning in 1C Metabolism and Their Interactions with Cofactors. Case: Study: Exercise Week 9 Metabolites in 1C metabolism Lecture: Metabolites in 1C Metabolism. Case Study Week 10 Folate and Folic Acid in Cancer. Lecture Folate and Folic Acid in Cancer. Case Study: GNMT I, II, III, and what’s next? Week 11 Dietary factors that affect 1C Metabolism, and the gene-nutrient interactions Factors affect 1C Metabolism-Energy Expenditure (KDIFCR) Week 12 1C Metabolism in Human Diseases. Lecture: Statistical Analyses for case control, RCT. Case Study: AJM, JN, Gut, CCR, WJG Week 13 1C Metabolism in Human Diseases. Lecture: B6 vitamers, Human Study Design Week 14 1C Metabolism in Human Diseases. Case Study: B6 in inflammation Week 15 1C Metabolism in Human Diseases. Lecture and case Study:1C in inflammation Term paper and homework discussions (I) Week 16 1C Metabolism in Human Diseases. Lecture and case Study: OCM during aging Term paper and homework discussions (II) Week 17 Term paper and homework discussions (III) Week 18 Term paper and homework discussions (IV)
Evaluation
In-class presentation (50%); class participation and discussions (25%); Term paper (25%)
Textbook & other References
1. Lecture printouts. 2. Handbook of Vitamins ISBN: 0-8247-0428-2, Third Edition (Clinical Nutrition in Health and Disease) by Robert B. Rucker (Author), John W. Suttie (Author), Donald B. McCormick (Author) 3. Advanced Nutrition and Human Metabolism. 5th ed. Seattle, WA. Nutritional biochemistry by Tom Brody. 2nd. Ed 4. Food and Nutrition in Translational Medicine Workshop from Stover PJ 5. Selected recent papers in the field.
Teaching Aids & Teacher's Website
Lecture printouts https://sites.google.com/email.nchu.edu.tw/chiang-lab-2021/publish?authuser=0
Office Hours
Monday Noon-1 pm
Sustainable Development Goals, SDGs
include experience courses：N

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Update Date, year/month/day：None	Printed Date, year/month/day：2025 / 1 / 22
The second-hand book website：http://www.myub.com.tw/