NCHU Course Outline

Course Name	(中) 動物病毒學文獻探討(一)(6292)
	(Eng.) Seminar on Animal Virology (I)
Offering Dept	Department of Veterinary Medicine
Course Type	Elective	Credits	1	Teacher	CHI-YOUNG WANG ect.
Department	Department of Veterinary Medicine/Graduate	Language	English	Semester	2024-FALL
Course Description	This class is to design as the journal club for the graduate students who are interested to acquire some advanced knowledge in the field of molecular microbiology and molecular virology. Students can learn how to design, interpret, and complete a scientific research proposal after reading papers.
Prerequisites				self-directed learning in the course	N

Relevance of Course Objectives and Core Learning Outcomes(%)			Teaching and Assessment Methods for Course Objectives
Course Objectives	Competency Indicators	Ratio(%)	Teaching Methods	Assessment Methods
Establishment of the basic reading ability for the graduate student. Training of the scientific research capacity for the graduate student. Understanding of the experiment techniques used in the molecular virology.			Discussion	Attendance Oral Presentation
Course Content and Homework/Schedule/Tests Schedule
Week Course Content Week 1 Canarypox and fowlpox viruses as recombinant vaccine vectors: a biological and immunological comparison. Antiviral Res. 88:53-63. Week 2 New insight into avian papillomavirus ecology and evolution from characterization of novel wild bird papillomaviruses. Front. Microbiol. 10:701. Week 3 Apoptosis triggered by ORF3 proteins of the circoviridae family. Frontiers in cellular and infection microbiology 10:609071 Week 4 Inhibitory effects of nitric oxide and gamma interferon on in vitro and in vivo replication of Marek’s disease virus. J. Virol. 74:3605-3612. Week 5 Cell permeabilization by poliovirus 2B viroporin triggers bystander permeabilization in neighbouring cells through a mechanism involving gap junctions. Cell. Microbiol. 12:1144-1157. Week 6 Inhibition of anti-viral stress granule formation by coronavirus endoribonuclease nsp15 ensures efficient replication. PLoS Pathog. 17(2):e1008690 Week 7 The herpes simplex virus host shutoff (vhs) RNase limits accumulation of double stranded RNA in infected cells: evidence for accelerated decay of duplex RNA. PLoS Pathog. 15(10):e1008111 Week 8 Student report:I Week 9 Characterization, functional and signaling elucidation of pigeon (Columba livia) interferon-gamma: knockdown p53 negatively modulates antiviral response. Dev. Comp. Immunol. 90:29-40. Week 10 Recovirus NS1-2 has viroporin activity that induces aberrant cellular calcium signaling to facilitate virus replication. mSphere 4:e00506-19. Week 11 Student report:II Week 12 Interferon gamma prevents infectious entry of human papillomavirus 16 via an L2-dependent mechanism. J. Virol. 91:e00168-17. Week 13 Encephalomyocarditis virus viroporin 2B activates NLRP3 inflammasome. PLoS Pathog. 8:e1002857 Week 14 Student report:III Week 15 Genome-wide classification of type I, type II, and type III interferon-stimulated genes in chicken fibroblasts. Vaccines 7:160 Week 16 Recombinant infectious bronchitis coronavirus Beaudette with the spike protein gene of the pathogenic M41 strain remains attenuated but induces protective immunity. Journal of Virology 78:13804-13811. Week 17 A reporter system for assaying influenza virus RNP functionality based on secreted Gaussia luciferase activity. Virol. J. 8:29 Week 18 Final discussion
Evaluation
The performance of report and discussion
Textbook & other References
Journal of Virology Journal of General Virology Virology Veterinary Virology Plos One Vaccine
Teaching Aids & Teacher's Website
Office Hours
Friday 4:00 PM-5:00 PM
Sustainable Development Goals, SDGs
include experience courses：N

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Update Date, year/month/day：None	Printed Date, year/month/day：2024 / 11 / 21
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