| Course Name |
(中) 微生物遺傳與基因體特論(一)(6079) |
| (Eng.) Topics in Microbial Genetics and Genomics(I) |
| Offering Dept |
Graduate Institute of Genomics and Bioinformatics |
| Course Type |
Elective |
Credits |
2 |
Teacher |
YING-TSONG CHEN |
| Department |
Graduate Institute of Genomics and Bioinformatics/Graduate |
Language |
中/英文 |
Semester |
2024-FALL |
| Course Description |
Microbial genomics is the study of the molecular organization of the genome, their content, and the genes they encode. DNA can be sequenced using different methods. Microbial genome can be sequenced using whole-genome shotgun sequencing in which random genomic DNA fragments are sequenced and then assembled by computer to give the complete genome. Analyzing bacterial genomes can be the foundations in investigating bacterial physiology, their genome structures, molecular evolution, antimicrobial resistance, pathogenesis and more. It will also help in preparing new vaccines and new drugs for the treatment of infections. Both experimental genomics and bioinformatic tools for microbial genomics will be introduced in the course. |
| Prerequisites |
|
self-directed learning in the course |
Y |
| Relevance of Course Objectives and Core Learning Outcomes(%) |
Teaching and Assessment Methods for Course Objectives |
| Course Objectives |
Competency Indicators |
Ratio(%) |
Teaching Methods |
Assessment Methods |
Introducing the critical topics in the development of genomics in bacteria and studying microbiome
|
|
|
| topic Discussion/Production |
| Discussion |
| Lecturing |
| Practicum |
|
| Oral Presentation |
| Internship |
| Written Presentation |
| Attendance |
| Assignment |
| Study Outcome |
| Quiz |
| Other |
|
| Course Content and Homework/Schedule/Tests Schedule |
| Week |
Course Content |
| Week 1 |
Introduction to the course |
| Week 2 |
DNA and RNA |
| Week 3 |
Determing DNA sequence - Sanger sequencing |
| Week 4 |
Determing DNA sequence - NGS |
| Week 5 |
Determing DNA sequence - Single molecular sequencing |
| Week 6 |
The concept of whole genome shotgun |
| Week 7 |
Bioinformatics basics - Linux |
| Week 8 |
Bioinformatics basics - Linux |
| Week 9 |
Bioinformatics basics - Linux |
| Week 10 |
Bioinformatics - Handling sequencing data |
| Week 11 |
Bioinformatics - Introducing assembly pipelines |
| Week 12 |
Bioinformatics - Annotation |
| Week 13 |
Bioinformatics - analyzing bacterial antimicrobial resistance and Virulence factors |
| Week 14 |
Bioinformatics - cgMLST and molecular phylogeny |
| Week 15 |
Bioinformatics - Comparative genomics of Bacteria |
| Week 16 |
Bioinformatics - Molecular Evolution of Bacterial Genomes |
| Week 17 |
self-directed learning |
| Week 18 |
self-directed learning |
|
| Evaluation |
| 專題研究、實作、報告與討論 |
| Textbook & other References |
Molecular Genetics of Bacteria 4th. Ed. Snyder & Peters, ASM Press 2012
Other selected paper and review articles
|
| Teaching Aids & Teacher's Website |
Teaching materials will be avaliable in eCampus
|
| Office Hours |
週一下午1:30-2:30
|
| Sustainable Development Goals, SDGs |
| include experience courses：N |
|