| Course Name |
(中) 微生物遺傳與基因體特論(二)(6069) |
| (Eng.) Topics in Microbial Genetics and Genomics (II) |
| Offering Dept |
Graduate Institute of Genomics and Bioinformatics |
| Course Type |
Elective |
Credits |
2 |
Teacher |
YING-TSONG CHEN |
| Department |
Graduate Institute of Genomics and Bioinformatics/Graduate |
Language |
中/英文 |
Semester |
2025-SPRING |
| Course Description |
This course operates as a mentoring program conducted off-site, which is exclusively for graduate students in the Graduate Institute of Genomics and Bioinformatics. By having genomic sequencing as our core technology, the Bacterial Genomics Core Laboratory is dedicated to the functional genomics studies of pathogenic bacteria, focusing on antimicrobial resistance and pathogenicity. This special topics course is open to student members of the research team and other research associates involved in collaborative research with our group. The course content will primarily focus on our interesting research topics, engaging in exploration of literature and knowledge related to specific research themes. Emphasis will also be placed on fostering self-learning skills, data collection, literature review proficiency, and the cultivation of English language proficiency in the context of the students' respective fields of expertise.Comparative sequencing of different pathogenic and commensal forms of microorganisms have improved our understandings of the mechanisms of pathogenesis and the transition between non-pathogenic and pathogenic varieties within the same species. It is becoming increasingly evident that some distinct genomic differences found in different microbes have a definite impact on pathogenic potential, adaptation to parasitic lifestyles and host/tissue tropism. Some examples in this context will be discussed in the course. Variation in gene content, especially the flexible or unstable part of the genome such as mobile elements and genomic islands, has been shown to influence phenotypes such as virulence and antimicrobial resistance. This course will be conducted in a face-to-face discussion format. In principle, only students from the Institute of Genomics and Bioinformatics can be accepted for this course.Since prokaryotes evolve largely by horizontal gene acquisition, vertical genome reduction and in-situ gene duplication strategies to shape an optimal repertoire of the genes and elements to support a successful lifestyle. The third part of the course will discuss the phenomena of lateral gene transfer, by which organisms acquire novel functions through harnessing functional attributes of some of the genes gained through such recombinational processes. Both experimental genomics and bioinformatic tools for microbial genomics will be introduced in the course.
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| Prerequisites |
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self-directed learning in the course |
Y |
| Relevance of Course Objectives and Core Learning Outcomes(%) |
Teaching and Assessment Methods for Course Objectives |
| Course Objectives |
Competency Indicators |
Ratio(%) |
Teaching Methods |
Assessment Methods |
Explore specific research themes related to microbial genetics and genomics.
Engage in literature review and knowledge exploration pertinent to selected research topics.
Foster self-directed learning skills among graduate students.
Enhance proficiency in data collection and literature reference reading.
Emphasize English language proficiency in the context of the students' specialized fields. |
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|
| topic Discussion/Production |
| Discussion |
|
| Oral Presentation |
| Internship |
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| Course Content and Homework/Schedule/Tests Schedule |
| Week |
Course Content |
| Week 1 |
1. Host Susceptibility and Bacterial Infectivity |
| Week 2 |
Paper review and discussion |
| Week 3 |
Paper review and discussion |
| Week 4 |
2. Host Resistance |
| Week 5 |
Paper review and discussion |
| Week 6 |
Paper review and discussion |
| Week 7 |
3. Genetic and Molecular Basis for Virulence |
| Week 8 |
Paper review and discussion |
| Week 9 |
Paper review and discussion |
| Week 10 |
4. Intracellular Growth |
| Week 11 |
Paper review and discussion |
| Week 12 |
Paper review and discussion |
| Week 13 |
5. Bacterial virulence Factors
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| Week 14 |
Paper review and discussion |
| Week 15 |
Paper review and discussion |
| Week 16 |
6. Antimicrobial Resistance |
| Week 17 |
self-direct learning |
| Week 18 |
self-direct learning |
|
| Evaluation |
Oral presentation 100%
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| Textbook & other References |
1.Bacterial Pathogenesis: A Molecular Approach
2.Selected paper and review articles
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| Teaching Aids & Teacher's Website |
Teaching materials will be avaliable in eCampus
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| Office Hours |
| 9~12AM Monday |
| Sustainable Development Goals, SDGs |
| include experience courses：N |
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