| Week |
Course Content |
| Week 1 |
Week 1 (2/20) Class Introduction (鄭) |
| Week 2 |
Week 2 (2/27) New hope for female infertility: Adult ovary stem cell (鄭)
1. Nature Vol 428 p145-150. Germline stem cells and follicular renewal in the postnatal mammalian ovary.
2. Cell 2005 Jul 29;122(2):303-15. Oocyte generation in adult mammalian ovaries by putative germ cells in bone marrow and peripheral blood.
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| Week 3 |
Week 3 (3/6) Are you bearing your own child (鄭)
1. Nature 2006 Jun 29;441(7097):1109-14.Ovulated oocytes in adult mice derive from non-circulating germ cells.
2. Nat Cell Biol 2009 May;11(5):631-6. Production of offspring from a germline stem cell line derived from neonatal ovaries.
3. Nat Med. 2012 Feb 26;18(3):413-21.Oocyte formation by mitotically active germ cells purified from ovaries of reproductive-age women.
|
| Week 4 |
Week 4 (3/13) Be all that you can be (鄭)
1. Nature. 2011 Jul 20;476(7358):101-4. DMRT1 prevents female reprogramming in the postnatal mammalian testis.
2. Cell. 2009 Dec 11;139(6):1130-42. Somatic sex reprogramming of adult ovaries to testes by FOXL2 ablation.
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| Week 5 |
Week 5 (3/20) Rejuvenation fountain (鄭)
1. Nature 2005 Feb 17;433(7027):760-4.Rejuvenation of aged progenitor cells by exposure to a young systemic environment
2. Nature 2011 Aug 31;477(7362):90-4. The ageing systemic milieu negatively regulates neurogenesis and cognitive function.
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| Week 6 |
Week 6 (3/27) iPS cells & stem cell therapy (鄭)
1. Science 2007 Dec 21;318(5858):1920-3. Treatment of Sickle Cell Anemia Mouse Model with iPS Cells Generated from Autologous Skin
2. Blood 2011October 27 118(17) 4599-4608 Site-specific gene correction of a point mutation in human iPS cells derived from an adult patient with sickle cell disease |
| Week 7 |
Week 7 (4/3) Make-up holiday for University Anniversary and Annual Sports Meet |
| Week 8 |
Week 8 (4/10) Getting unlimited stem cells (鄭)
1. Nature 2006 Jan 12;439(7073):212-5. Generation of nuclear transfer-derived pluripotent ES cells from cloned Cdx2-deficient blastocysts
2. Cell 2008 April 18, 133, 250–264, Direct Reprogramming of Terminally Differentiated Mature B Lymphocytes to Pluripotenc
|
| Week 9 |
Week 9 (4/17) Gene editing with CRISPR/Cas systems (鄭)
1. PNAS December 26, 2019 116 (52) 26846-26852; CRISPR/Cas9-based targeted genome editing for correction of recessive dystrophic epidermolysis bullosa using iPS cells. |
| Week 10 |
week 10 (4/24) Beauty is only skin deep (鄭)
1. Nature. 2007 May 17;447(7142):316-20. Wnt-dependent de novo hair follicle regeneration in adult mouse skin after wounding.
2. 2008 Jan 17;451(7176):340-4. Cyclic dermal BMP signaling regulates stem cell activation during hair regeneration
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| Week 11 |
Week 11 (5/1) Tooth regeneration I(鄭)
1. Antagonistic Functions of USAG-1 and RUNX2 during Tooth Development
2. Interactions between BMP-7 and USAG-1 (Uterine Sensitization-Associated Gene-1) Regulate Supernumerary Organ Formations |
| Week 12 |
(5/8) Tooth regeneration II(鄭)
3. Local application of Usag-1 siRNA can promote tooth regeneration in Runx2-deficient mice
4. Anti-USAG-1 therapy for tooth regeneration through enhanced BMP signaling
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| Week 13 |
(5/15) TBA (鄭) |
| Week 14 |
(5/22) TBA (鄭) |
| Week 15 |
(5/29) TBA (鄭) |
| Week 16 |
(6/5) Gene engineering (鄭) |
| Week 17 |
(6/12) Spontaneous Laerning |
| Week 18 |
(6/19) Spontaneous Laerning |