NCHU Course Outline
Course Name (中) 老化及老化相關疾病特論(5101)
(Eng.) Ageing and Ageing-Associated Diseases
Offering Dept Department of Life Sciences
Course Type Elective Credits 2 Teacher Chih-Yi Gabriela Lin
Department Department of Life Sciences/Graduate Language English Semester 2025-FALL
Course Description The course aims to equip students with a thorough comprehension of ageing, specifically the molecular-level changes that underlie age-related diseases. By the end of the course, students will have a comprehensive understanding of ageing biology, the hallmarks of ageing, and the molecular changes that drive age-related diseases. They will also be familiar with current research progress in the field and the potential interventions and treatments available.
Prerequisites
self-directed learning in the course Y
Relevance of Course Objectives and Core Learning Outcomes(%) Teaching and Assessment Methods for Course Objectives
Course Objectives Competency Indicators Ratio(%) Teaching Methods Assessment Methods
Provide students with an understanding of ageing biology and the dynamic changes that contribute to age-related diseases at the molecular level.
8.Realizing the functions and regulatory mechanisms of biological molecules
9.The passion for seeking new development of biology
50
50
Discussion
Lecturing
Oral Presentation
Other
Assignment
Course Content and Homework/Schedule/Tests Schedule
Week Course Content
Week 1 What is ageing?
Week 2 Theories of ageing
Week 3 Genomic instability in ageing
Week 4 Epigenetics of longevity and ageing
Week 5 10/10 National Day
Week 6 The role of telomere in ageing
Week 7 10/25 Taiwan Restoration Day
Week 8 Cellular ageing I
Week 9 Cellular ageing II
Week 10 Immunosenescence I
Week 11 Immunosenescence II
Week 12 Neurodegenerative diseases: AD, PD, HD, ALS
Week 13 Cardiovascular diseases
Week 14 Ageing and respiratory diseases: COPD & IPF
Human premature ageing
Week 15 Endocrine diseases: Type 2 Diabetes Mellitus, Osteoporosis & Hyperparathyroidism
Week 16 Endocrine diseases: Andropause & Menopause
self-directed
learning
   02.Viewing multimedia materials related to industry and academia.

Evaluation
Class engagement: 50%; Assignments: 50%
Textbook & other References
1. Fang, E. F.; Bergersen, L. H.; Gilmour, B. C. Molecular, Cellular, and Metabolic Fundaments of Human Aging; Academic Press: London, UK.
2. Yamada H, Yuji N, editors. Anti-Aging Medicine: Basics and Clinical Practice [Internet]. Singapore: Springer Nature Singapore; 2024 [cited 2025 Feb 14]. Available from: https://link.springer.com/10.1007/978-981-97-8514-8
3. Bennett G. Senotherapy: A Potential Pharmacological Strategy for Prolonging Human Lifespan and Healthspan [Internet]. Singapore: Springer Nature Singapore; 2024 [cited 2025 Feb 14]. (SpringerBriefs in Modern Perspectives on Disability Research). Available from: https://link.springer.com/10.1007/978-981-97-3637-9

Selected papers from high-profile journals.
Teaching Aids & Teacher's Website
ilearning
Office Hours
Appointment
Sustainable Development Goals, SDGs(Link URL)
03.Good Health and Well-Beinginclude experience courses:N
Please respect the intellectual property rights and use the materials legally.Please respect gender equality.
Update Date, year/month/day:2025/08/28 22:52:33 Printed Date, year/month/day:2025 / 10 / 19
The second-hand book website:http://www.myub.com.tw/