NCHU Course Outline
Course Name (中) 老化及老化相關疾病特論(5101)
(Eng.) Ageing and Ageing-Associated Diseases
Offering Dept Department of Life Sciences
Course Type Elective Credits 2 Teacher Chih-Yi Gabriela Lin
Department Department of Life Sciences/Graduate Language English Semester 2025-FALL
Course Description The course aims to equip students with a thorough comprehension of ageing, specifically the molecular-level changes that underlie age-related diseases. By the end of the course, students will have a comprehensive understanding of ageing biology, the hallmarks of ageing, and the molecular changes that drive age-related diseases. They will also be familiar with current research progress in the field and the potential interventions and treatments available.
Prerequisites
self-directed learning in the course Y
Relevance of Course Objectives and Core Learning Outcomes(%) Teaching and Assessment Methods for Course Objectives
Course Objectives Competency Indicators Ratio(%) Teaching Methods Assessment Methods
Provide students with an understanding of ageing biology and the dynamic changes that contribute to age-related diseases at the molecular level.
Discussion
Lecturing
Oral Presentation
Other
Written Presentation
Course Content and Homework/Schedule/Tests Schedule
Week Course Content
Week 1 What is ageing?
Week 2 2/28 Peace Memorial Day
Week 3 Evolution theories of ageing
Week 4 Genomic instability in ageing
Week 5 The role of telomere in ageing
Week 6 Epigenetics of longevity and ageing
Week 7 Mitochondrial dysfunction and dysregulated proteostasis
4/4 Tomb Sweeping Festival
Week 8 Cellular ageing
Week 9 Immunosenescence
Week 10 Senotherapeutics
Week 11 Neurodegenerative diseases: AD, PD
Week 12 Neurodegenerative diseases: HD, ALS
Week 13 Cardiovascular diseases
Hematopoietic stem cells: CHIP
Week 14 Ageing and respiratory diseases: COPD & IPF
Human premature ageing
Week 15 5/30 Adjusted holiday for Dragon Boat Festival holiday
Week 16 Endocrine diseases: Type 2 Diabetes Mellitus, Osteoporosis & Hyperparathyroidism, Andropause & Menopause Self-directed learning
Self-directed learning
self-directed
learning

Evaluation
Oral presentation: 50%; Writing presentation: 30%; Class engagement: 20%
Textbook & other References
1. Fang, E. F.; Bergersen, L. H.; Gilmour, B. C. Molecular, Cellular, and Metabolic Fundaments of Human Aging; Academic Press: London, UK.
2. Yamada H, Yuji N, editors. Anti-Aging Medicine: Basics and Clinical Practice [Internet]. Singapore: Springer Nature Singapore; 2024 [cited 2025 Feb 14]. Available from: https://link.springer.com/10.1007/978-981-97-8514-8
3. Bennett G. Senotherapy: A Potential Pharmacological Strategy for Prolonging Human Lifespan and Healthspan [Internet]. Singapore: Springer Nature Singapore; 2024 [cited 2025 Feb 14]. (SpringerBriefs in Modern Perspectives on Disability Research). Available from: https://link.springer.com/10.1007/978-981-97-3637-9

Selected papers from high-profile journals.
Teaching Aids & Teacher's Website
ilearning
Office Hours
Appointment
Sustainable Development Goals, SDGs(Link URL)
include experience courses:N
Please respect the intellectual property rights and use the materials legally.Please respect gender equality.
Update Date, year/month/day:None Printed Date, year/month/day:2025 / 6 / 18
The second-hand book website:http://www.myub.com.tw/