| 課程簡述 |
(中) 非編碼核醣核酸在生物體一直有著舉足輕重的角色，凡舉核糖体核糖核酸、轉運核糖核酸與核内小分子核糖核酸皆掌控著著細胞生長與存活的基本需求。過去十年，隨著分子生物學與生物資訊學的發展，有數個新穎類別的非編碼核醣核酸被陸續發現與研究。這個課程將涵蓋其中的干擾核醣核酸、微型核醣核酸、CRISPR/Cas9與環型核醣核酸。除此之外，近兩三年新興的表觀轉錄體學，其主要描述了帶有特定轉錄後修飾的核醣核酸具有不同生物活性。透過完成這一連串的課程單元，學生們可以獲取關於功能性核醣核酸的專業知識與技能，以應用於現行的專題研究或未來生技相關之研發工作。
(Eng.) The traditional noncoding RNAs such as ribosomal RNA, tRNA and small nucleolar RNA control the pivotal processes required for cell survival and growth. With the advance of molecular biology and bioinformatic analyses, there are few more classes of noncoding RNAs discovered in the past decade. This course will cover the topic of RNA interference, microRNA and circular RNA. In addition, the new emerging field of epitranscriptomics which coined from the epigenetics will discuss the differentially processed RNA molecules with particular modification. Through completing the course, the students would gain advanced knowledge about the functional roles of noncoding RNA, and the ability to incorporate these materials and ideals into their own current works or careers in the near future.
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