| 課程與核心能力關聯配比(%) |
課程目標之教學方法與評量方法 |
| 課程目標 |
核心能力 |
配比(%) |
教學方法 |
評量方法 |
1. To understand the replication cycle of virus and how virus finish its life cycle by using host factors.
2. To explore how antiviral is developed and how antivirals work on viruses.
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| 1.應用動物醫學、病理學及生物醫學專業知能 |
| 3.病理生物醫學訓練、致病機理研究及生技研發技術等關鍵能力的培養 |
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| 授課內容(單元名稱與內容、習作/每週授課、考試進度-共18週) |
| 週次 |
授課內容 |
| 第1週 |
1. Overview of DNA virus life cycle
2. Overview of RNA virus life cycle
3. Overview of antiviral drug discovery and development I
4. Overview of antiviral drug discovery and development II
5. Antiviral drug targets I
6. Antiviral drug targets II
7. Strategies to design antiviral drugs I
8. Strategies to design antiviral drugs II
9. Perspectives for the therapy against viruses
10. Viral invasion of the interferon system: novel targets for drug discovery I
11. Viral invasion of the interferon system: novel targets for drug discovery II
12. Structural biology of flaviviral replication and opportunities for drug design
13. West nile virus: new targets for potential antiviral drugs
14. Antiviral strategies for Ebola virus
15. S-adenosylhomocysteine hydrolase inhibitors as a source of anti-filovirus agents
16. IMPDH inhibitors: Discovery of antiviral agents against emerging diseases
17. Lethal mutagenesis: exploiting error-prone replication of riboviral therapy
18. Oral presentation |
| 第2週 |
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| 第3週 |
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| 第4週 |
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| 第5週 |
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| 第6週 |
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| 第7週 |
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| 第8週 |
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| 第9週 |
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| 第10週 |
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| 第11週 |
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| 第12週 |
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| 第13週 |
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| 第14週 |
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| 第15週 |
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| 第16週 |
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| 第17週 |
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| 第18週 |
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| 學習評量方式 |
Examination, Power point presentation, and writing assignment
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| 教科書＆參考書目(書名、作者、書局、代理商、說明) |
1. Advances in antiviral drug design, E. de Clercq, Elsevier, 2007
2. Antiviral Drugs: From Basic Discovery Through Clinical Trials, Wieslaw M. Kazmierski, Wiley, 2011
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| 課程教材（教師個人網址請列在本校內之網址） |
https://web2-sso.nchu.edu.tw/pweb/index2.php?pid=530
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| 課程輔導時間 |
Wednesday 11:00-12:00
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| 聯合國全球永續發展目標 |
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