國立中興大學教學大綱
課程名稱 (中) 動物毒物病理學(二)(6489)
(Eng.) Toxicologic Pathology in Animals (II)
開課單位 獸病所
課程類別 選修 學分 2 授課教師 廖俊旺
選課單位 獸病所 / 碩士班 授課使用語言 中文 英文/EMI N 開課學期 1122
課程簡述 (中) 本課程將介紹有關毒性藥物及化學物質對體內各系統器官所產生之非增殖性及增殖性(腫瘤)病理變化及理論,包括:神經系統、心血管、血液、泌尿、消化、骨骼、肌肉、內分泌、生殖、感官系統等體內各器官所引起之細胞病理變化及病理學評估之介紹。
(Eng.) This course will introduce the advance toxic alterations of non-proliferative and proliferative (tumor) lesions of drugs and chemicals in body, including nervous, cardiovascular, urinary, digestive, skeletal muscular, and reproductive systems in animals will be discussed.


先修課程名稱
課程含自主學習 N
課程與核心能力關聯配比(%) 課程目標之教學方法與評量方法
課程目標 核心能力 配比(%) 教學方法 評量方法
(中) 毒物病理學特論(二)為綜合毒理學與病理學之研究,主要探討毒物對體內各系統之細胞結構所引起之非增殖性及增殖性(腫瘤)之病變及作用機制,並提供毒物影響之整體評估概念。
(Eng.) Advance toxicologic pathology (II) in animals is used to elucidate the non- proliferative and proliferative (tumor) lesions and mechanisms of toxicants in various systems of animals. The aims of this course will provide and promote student’s logics and study conceptions in the toxicity research.

1.應用動物醫學、病理學及生物醫學專業知能
2.獸醫病理學、微生物學及生物醫學之實驗操作技術
3.病理生物醫學訓練、致病機理研究及生技研發技術等關鍵能力的培養
4.邏輯思考、推理分析、問題發問及溝通技巧的應用
50
10
20
20
講授
測驗
書面報告
口頭報告
授課內容(單元名稱與內容、習作/每週授課、考試進度-共18週)
週次 授課內容
第1週 Nomenclature
第2週 Hepatobiliary system-1
第3週 Hepatobiliary system-2
第4週 Urinary system-1
第5週 Urinary system-2
第6週 Respiratory system-1
第7週 運動會補假
第8週 期中考
第9週 Respiratory system-2
第10週 Male reproductive system-1
第11週 Male reproductive system-2
第12週 Female reproductive system-1
第13週 Female reproductive system-2
第14週 Mammary gland and exocrine glands
第15週 Gastrointestinal tract
第16週 期末考
第17週 自主學習(參加相關的演講、研討會或教師指定教材)
第18週 自主學習(參加相關的演講、研討會或教師指定教材)
學習評量方式
評分標準:出席:20%、自主學習作業:10%、期中考:35%、期末考:35%,共100 分。
教科書&參考書目(書名、作者、書局、代理商、說明)
教材:
Berridge BR, Mowat V, Nagai H, Nyska A, Okazaki Y, Clements PJ, Rinke M, Snyder PW, Boyle MC, Wells MY. 2016. Non-proliferative and proliferative lesions of the cardiovascular system of the rat and mouse. J Toxicol Pathol.;29(3 Suppl):1S-47S.
Creasy D, Bube A, Rijk Ed, Kandori H, Kuwahara M, Masson R, Nolte T, Reams R, Regan K., Rehm S, Rogerson P, and Whitney K. 2012. Proliferative and nonproliferative lesions of the rat and mouse male reproductive system. Toxicol Pathol. 40: 40S-121S.
Dixon D, Alison R, Bach U, Colman K, Foley GL, Harleman JH, Haworth R, Herbert R, Heuser A, Long G, Mirsky M, Regan K, Van Esch E, Westwood FR, Vidal J, Yoshida M. 2014. Nonproliferative and proliferative lesions of the rat and mouse female reproductive system. J Toxicol Pathol. 27(3-4 Suppl):1S-107S.
Fossey S, Vahle J, Long P, Schelling S, Ernst H, Boyce RW, Jolette J, Bolon B, Bendele A, Rinke M, Healy L, High W, Roth DR1 Boyle M, Leininger J. 2016. Nonproliferative and proliferative lesions of the rat and mouse skeletal tissues (bones, joints, and teeth). J Toxicol Pathol. 229 (3 Suppl):49S-103S.
Frazier KS, Seely JC, Hard GC, Betton G, Burnett R, Nakatsuji S, Nishikawa A, Durchfeld-Meyer B, and Bube A. 2012. Proliferative and nonproliferative lesions of the rat and mouse urinary system. Toxicol Pathol. 40: 14S-86S.
Greaves, P., Chouinard, L., Ernst, H., Mecklenburg, L., Pruimboom-Brees, I.M., Rinke, M., Rittinghausen, S., Thibault, S., Von Erichsen, J., Yoshida, T. 2013. Proliferative and non-proliferative lesions of the rat and mouse soft tissue, skeletal muscle and mesothelium. J Toxicol Pathol. 26 (3 Suppl): 1S–26S.
Kaufmann W, Bolon B, Bradley A, Butt M, Czasch S, Garman RH, George C, Gröters S, Krinke G, Little P, McKay J, Narama I, Rao D, Shibutani M, and Sills R. 2012. Proliferative and nonproliferative lesions of the rat and mouse central and peripheral nervous systems. Toxicol Pathol. 40 (4 Suppl):87S-157S.
Mecklenburg L, Kusewitt D, Kolly C, Treumann S, Adams ET, Diegel K, Yamte J, Kaufmann W, Müller S, Danilenko D, and Bradley A. 2013. Proliferative and non-proliferative lesions of the rat and mouse integument. J Toxicol Pathol. 26 (3 Suppl): 27S–57S.
Mann PC, Vahle J, Keenan CM, Baker JF, Bradley AE, Goodman DG, Harada T, Herbert R, Kaufmann W, Kellner R, Nolte T, Rittinghausen S, Tanaka T. 2012. International harmonization of toxicologic pathology nomenclature: an overview and review of basic principles. Toxicol Pathol. 40(4 Suppl):7S-13S.
Nolte T, Brander-Weber P, Dangler C, Deschl U, Elwell MR, Greaves P, Hailey R, Leach MW, Pandiri AR, Rogers A, Shackelford CC, Spencer A, Tanaka T, and Ward JM. 2016. Nonproliferative and proliferative lesions of the gastrointestinal tract, pancreas and salivary glands of the rat and mouse. J Toxicol Pathol. 29(1 Suppl):1S-125S.
Rudmann D, Cardiff R, Chouinard L, Goodman D, Küttler K, Marxfeld H, Molinolo A, Treumann S, Yoshizawa K.; INHAND Mammary, Zymbal’s, Preputial, and Clitoral Gland Organ Working Group. 2012. Proliferative and nonproliferative lesions of the rat and mouse mammary, Zymbal’s, preputial, and clitoral glands. Toxicol Pathol. Aug;40(6 Suppl):7S-39S.
Renne R, Brix A, Harkema J, Herbert R, Kittel B, Lewis D, March T, Nagano K, Pino, M, Rittinghausen S, Rosenbruch M, Tellier P, and Wohrmann T. 2012. Proliferative and nonproliferative lesions of the rat and mouse respiratory tract. Toxicol Pathol. 37: 5S-73S.
Thoolen B, Maronpot RR, Harada T, Nyska A, Rousseaux C, Nolte T, Malarkey DE, Kaufmann W, Küttler K, Deschl U, Nakae D, Gregson R, Vinlove MP, Brix AE, Singh B, Belpoggi F, and Ward JM. 2010. Proliferative and non- proliferative lesions of the rat and moues hepatobiliary system. Toxicol Pathol. 38 (7 Suppl):5S-81S.
Rubcll Z, Arceo RJ , Bishop SP,Elwell MR, Kerns WD, Mesfin GM, Sandusky GE, and Van Vleet JF. 2000. Non-proliferative lesions of the heart and vasculature in rats. CV-l. In: Guides for Toxicologic Pathology, STP/ARP/AFlP. Washington, DC.
Westwood FR. 2008. The female rat reproductive cycle: A practical histological guide to staging. Toxicol Pathol. 36: 375-384.
Willard-Mack CL, Elmore SA, Hall WC, Harleman J, Kuper CF, Losco P, Rehg JE, Rühl-Fehlert C, Ward JM, Weinstock D, Bradley A, Hosokawa S, Pearse G, Mahler BW, Herbert RA, Keenan CM (2021) Nonproliferative and Proliferative Lesions of the Rat and Mouse Hematolymphoid System. Toxicol Pathol 47: 665–783
課程教材(教師個人網址請列在本校內之網址)
i-learning

課程輔導時間
週二上午10:10-12:00

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