| 課程簡述 |
This course operates as a mentoring program conducted off-site, which is exclusively for graduate students in the Graduate Institute of Genomics and Bioinformatics. By having genomic sequencing as our core technology, the Bacterial Genomics Core Laboratory is dedicated to the functional genomics studies of pathogenic bacteria, focusing on antimicrobial resistance and pathogenicity. This special topics course is open to student members of the research team and other research associates involved in collaborative research with our group. The course content will primarily focus on our interesting research topics, engaging in exploration of literature and knowledge related to specific research themes. Emphasis will also be placed on fostering self-learning skills, data collection, literature review proficiency, and the cultivation of English language proficiency in the context of the students' respective fields of expertise.Comparative sequencing of different pathogenic and commensal forms of microorganisms have improved our understandings of the mechanisms of pathogenesis and the transition between non-pathogenic and pathogenic varieties within the same species. It is becoming increasingly evident that some distinct genomic differences found in different microbes have a definite impact on pathogenic potential, adaptation to parasitic lifestyles and host/tissue tropism. Some examples in this context will be discussed in the course. Variation in gene content, especially the flexible or unstable part of the genome such as mobile elements and genomic islands, has been shown to influence phenotypes such as virulence and antimicrobial resistance. This course will be conducted in a face-to-face discussion format. In principle, only students from the Institute of Genomics and Bioinformatics can be accepted for this course.Since prokaryotes evolve largely by horizontal gene acquisition, vertical genome reduction and in-situ gene duplication strategies to shape an optimal repertoire of the genes and elements to support a successful lifestyle. The third part of the course will discuss the phenomena of lateral gene transfer, by which organisms acquire novel functions through harnessing functional attributes of some of the genes gained through such recombinational processes. Both experimental genomics and bioinformatic tools for microbial genomics will be introduced in the course.
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