國立中興大學教學大綱
課程名稱 (中) 維生素與單碳代謝導論(5214)
(Eng.) Introduction of Vitamins in One Carbon Metabolism
開課單位 食生碩
課程類別 選修 學分 2 授課教師 蔣恩沛
選課單位 食生系 / 學士班 授課使用語言 英文 英文/EMI N 開課學期 1141
課程簡述 This course will introduce the basic concepts of one-carbon metabolism (OCM) and the functions of vitamin coenzymes involved in the main reactions I our body. The goal of the course is to introduce the nutritional biochemistry in OCM in detail to students who are conducting research in related fields, and to deeply explore the latest research on OCM in recent years. It includes the main vitamin cofactors of enzymes in OCM, cellular absorption, vitamin uptake and retention, assimilation and dissimilation of folic acid, folic acid antagonists, regulation of folate dependent transmethylation, transsulfuration and homocysteine remethylation, genetic variability and dietary effects on OCM, cellular and genetic patterns on metabolic kinetics in human diseases and therapies
先修課程名稱
課程與核心能力關聯配比(%) 課程目標之教學方法與評量方法
課程目標 核心能力 配比(%) 教學方法 評量方法
to introduce the basic concepts of one-carbon metabolism (OCM) and the functions of vitamin coenzymes involved in the main reactions I our body. The goal of the course is to introduce the nutritional biochemistry in OCM in detail to students who are conducting research in related fields, and to deeply explore the latest research on OCM in recent years. It includes the main vitamin cofactors of enzymes in OCM, cellular absorption, vitamin uptake and retention, assimilation and dissimilation of folic acid, folic acid antagonists, regulation of folate dependent transmethylation, transsulfuration and homocysteine remethylation, genetic variability and dietary effects on OCM, cellular and genetic patterns on metabolic kinetics in human diseases and therapies.
介紹單碳代謝基本概念以及參與其中主要反應之維生素輔酶之功能。課程之目標為對進行相關領域研究之同學詳盡介紹單碳代謝中之營養生化、並深入探討近年來生素與單碳代謝的最新研究。將包括單碳代謝中之酵素的維生素輔因子、細胞對於葉酸的吸收、滯留、同化及異化作用、葉酸拮抗藥物、轉甲基、轉硫與同半胱胺酸再甲基作用之調控、基因的變異性與飲食對單碳代謝的影響、細胞模式與遺傳性老鼠的模式、單碳代謝與疾病。
講授
討論
專題探討/製作
其他
口頭報告
書面報告
出席狀況
作業
授課內容(單元名稱與內容、習作/每週授課、考試進度-共16週加自主學習)
週次 授課內容
第1週 Introduction & Overview
第2週 Nutrient-Genome Interactions in 1C metabolism in Human Health. Lecture
Nutrient-Genome Interactions in 1C metabolism in Human Health. Case Study: MTHFR in LEUKEMIA
第3週 Nutrient-Genome Interactions in 1C metabolism in Human Health. Case Study: MTHFR and MTX efficacy
第4週 Drug-Genome Interactions in 1C metabolism. Case Study: Drug and gene interactions, (DMARDs MTX, SSZ, Pred, CsA, LEF)
第5週 Drug-Genome Interactions in 1C metabolism. Case Study: NSADIs
第6週 Enzymes in 1C Metabolism & Their Interactions with Cofactors. Lecture
Partitioning in 1C Metabolism and Their Interactions with Cofactors. Lecture
第7週 Partitioning in 1C Metabolism and Their Interactions with Cofactors. Case: Study: SHMT I. II. MTHFS
第8週 Metabolites in 1C metabolism Lecture: glycine, formate, choline, etc
第9週 Metabolites in 1C Metabolism. Case Study: GCS, GLY, and what’s next?
第10週 Folate and Folic Acid in Cancer. Lecture
Folate and Folic Acid in Cancer. Case Study: GNMT I, II, III, and what’s next?
第11週 Dietary factors that affect 1C Metabolism-Sugar, High Fat, Calorie Restriction, Ketogenic Diets, Intermittent fasting, and the gene-nutrient interactions with GNMT
第12週 Factors affect 1C Metabolism-Energy Expenditure. Case Study: Aerobic vs. Anaerobic exercise, High Fat vs. Calorie RestrictionHF
第13週 Dietary factors affect 1C Metabolism-phytochemicals. Case: SFN and PQQ
Dietary factors affect 1C Metabolism-food factors. Case Study: Natural and Artificial Sweeteners
第14週 1C Metabolism in Human Diseases. Lecture: Statistical Analyses for case control, RCT. Case Study: AJM, JN, Gut, CCR, WJG
第15週 1C Metabolism in Human Diseases. Lecture: B6 vitamers, Human Study Design
1C Metabolism in Human Diseases. Case Study: AR1, AR2, JPET, AJCN, and what’s the next?
1C Metabolism in Human Diseases. Lecture and case Study: inflammation, PF, Sarcopenia?
1C Metabolism in Human Diseases. Lecture and case Study: type 1 & type 2 DB, Metformin and Actros.
第16週 Term paper and homework discussions (I)
1C Metabolism in microbes? Term paper and homework discussions (II)
Term paper and homework discussions (III)
自主學習
內容		    01.參與專業論壇、講座、企業分享等產官學研相關交流活動
   03.製作專題報告
學習評量方式
1. Oral presentation
2. Written report (term-paper or proposal)
3. Class participation and discussions
教科書＆參考書目(書名、作者、書局、代理商、說明)
Course materials
1. Lecture printouts.
2. Handbook of Vitamins ISBN: 0-8247-0428-2, Third Edition (Clinical Nutrition in Health and Disease) by Robert B. Rucker (Author), John W. Suttie (Author), Donald B. McCormick (Author)
3. Advanced Nutrition and Human Metabolism. 5th ed. Seattle, WA. Nutritional biochemistry by Tom Brody. 2nd. Ed
4. Food and Nutrition in Translational Medicine Workshop from Stover PJ
5. Selected recent papers from the field.
課程教材（教師個人網址請列在本校內之網址）
Course materials
1. Lecture printouts.
2. Handbook of Vitamins ISBN: 0-8247-0428-2, Third Edition (Clinical Nutrition in Health and Disease) by Robert B. Rucker (Author), John W. Suttie (Author), Donald B. McCormick (Author)
3. Advanced Nutrition and Human Metabolism. 5th ed. Seattle, WA. Nutritional biochemistry by Tom Brody. 2nd. Ed
4. Food and Nutrition in Translational Medicine Workshop from Stover PJ
5. Selected recent papers from the field.
課程輔導時間
by appointment (另與教師個別約時間)
聯合國全球永續發展目標(連結網址)
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