| Course Name |
(中) 圖像解析分子結構實務(5193) |
| (Eng.) Practical Approach of Biomolecular Graphics and Structural Analysis |
| Offering Dept |
Graduate Institute of Biochemistry |
| Course Type |
Elective |
Credits |
3 |
Teacher |
Wen-Ting Lo |
| Department |
Department of Life Sciences / Undergraduate |
Language |
Chinese |
英文/EMI |
|
Semester |
2024-FALL |
| Course Description |
熟悉運用蛋白資料庫包含PDB, EM, AI所建置的蛋白質資料庫，分析並學習3D分子結構視覺軟體，藉由結構瞭解生化分子的生化功能。熟悉使用結構視覺軟體, 利用軟體分析的生化分子結構以及展示運用。讓學生培養出分析生化分子結構的能力，能夠根據蛋白質結構所提供資訊息，推測出蛋白質的功能，並設計實驗去印證自己的假設。上課後學生會使用分子結構預測軟體，結構軟體(pymol)，瞭解分子結構座標模式，瞭解分子的生化功能與結構關連性的範例，能由分子結構參考文獻，設計及繪製分子結構圖，演示分子的生化功能。
Proficient in using major protein databases to retrieve and understand protein structures. The lectures will provide instruction on utilizing 3D molecular structure visualization software to analyze and learn the biochemical functions of biomolecules through their structures. This involves the combination of structural analysis software to analyze and demonstrate structure-function relationships.
During the lecture, students will perform hands-on activities with molecular structure prediction software, structural software (e.g., PyMOL), and other analysis tools to understand molecular structure coordinate models and the relationship between biochemical functions and structures. Based on selected literature, students will learn how to present structural biology works. |
| Prerequisites |
|
self-directed learning in the course |
Y |
| Relevance of Course Objectives and Core Learning Outcomes(%) |
Teaching and Assessment Methods for Course Objectives |
| Course Objectives |
Competency Indicators |
Ratio(%) |
Teaching Methods |
Assessment Methods |
| 運用AI模型建置大數據資料庫，分析並學習3D分子結構視覺軟體，瞭解生化分子的結構及功能。 |
| 6.The research development of biotechnology |
|
|
| topic Discussion / Production |
| Exercises |
| Discussion |
| Lecturing |
|
| Attendance |
| Written Presentation |
| Oral Presentation |
| Assignment |
|
| Course Content and Homework/Schedule/Tests Schedule |
| Week |
Course Content |
| Week 1 |
課程介紹-3D分子結構 |
| Week 2 |
Protein data bank 介紹 |
| Week 3 |
PDB分子座標格式介紹 |
| Week 4 |
蛋白質結構預測技術演變 |
| Week 5 |
結構預測的操作與應用 |
| Week 6 |
結構分析與蛋白質功能分析 |
| Week 7 |
結構分析與藥物發展 |
| Week 8 |
期中測驗及練習:生化分子結構觀念測驗以及練習預測蛋白質結構並進行結構以及功能分析(課堂操作) |
| Week 9 |
PyMol軟體基本操作 |
| Week 10 |
PyMol軟體基本操作 |
| Week 11 |
PyMol軟體進階操作 |
| Week 12 |
PyMol動畫製作 |
| Week 13 |
PyMol動畫製作 |
| Week 14 |
分析Protein ligand interactions and protein ligand pocket |
| Week 15 |
蛋白質結構實作分析 |
| Week 16 |
利用PyMol製作書報討論 |
| Week 17 |
自主學習-參與學期中生科院任一場次專題演講並繳交心得報告 |
| Week 18 |
自主學習-參與學期中生科院任一場次專題演講並繳交心得報告 |
|
| Evaluation |
| 蛋白結構預測以及功能分析操作實作; 利用分子結構動畫來製作書報討論 |
| Textbook & other References |
| 教師PPT |
| Teaching Aids & Teacher's Website |
| 教師PPT |
| Office Hours |
| 課程結束後 |
| Sustainable Development Goals, SDGs |
| 04.Quality Education | include experience courses：N |
|