國立中興大學教學大綱
課程名稱 (中) 天然物生物活性篩選技術與實作(6853)
(Eng.) Techniques and Practice in Bioactivity Screening of Natural Products
開課單位 代謝碩士學程
課程類別 選修 學分 3 授課教師 顏佩翎
選課單位 代謝碩士學程 / 碩士班 授課使用語言 中/英文 開課學期 1151
課程簡述 This course provides students with practical and theoretical training in advanced functional screening strategies. Through lectures, laboratory practices, and project-based experiments, students will learn how to design, execute, and analyze screening assays to evaluate the biological activity of natural products. Emphasis is placed on lifespan, reproduction, locomotion, stress resistance, and behavior. Students will gain experience in assay optimization, troubleshooting, imaging, data visualization, and scientific presentation. The course culminates in a group project where students conduct a full functional screening study and present their findings.
先修課程名稱
課程與核心能力關聯配比(%) 課程目標之教學方法與評量方法
課程目標 核心能力 配比(%) 教學方法 評量方法
1. To cultivate students’ understanding of the fundamental principles and practical techniques of bioactivity screening of natural products.
2. To develop students’ hands-on skills in bioactivity screening using cellular and model organism systems. interpretation.
3. To enhance students’ ability in bioactivity data analysis and quality control.
討論
講授
書面報告
出席狀況
口頭報告
作業
授課內容(單元名稱與內容、習作/每週授課、考試進度-共16週加自主學習)
週次 授課內容
第1週 Introduction to Screening Concepts
第2週 Experimental Design: Controls, Replicates, Statistical Power
第3週 Lab: Synchronization and Setup
第4週 Phenotypic Assays Overview
第5週 Lab: Reproductive and Developmental Assays
第6週 Lab: Stress Resistance Assay
第7週 Lab: Locomotion Assay
第8週 Midterm Presentation: Functional Screening Proposal
第9週 Project Launch: Sample Selection & Screening Workflow Planning
第10週 Project Lab 1: Setup of Assay (based on group topic)
第11週 Progress Presentation I: Early Observations & Problem-solving Workshop
第12週 Project Lab 2: Behavior (based on group topic)
第13週 Progress Presentation II: Preliminary Results & Problem-solving Workshop
第14週 Project Lab 3: Behavior (based on group topic)
第15週 Data Processing and Visualization
第16週 Final Project Presentations
自主學習
內容		    03.製作專題報告
After completing the experiments, students are required to independently organize and analyze their experimental data, and to interpret the screening results through figures and concise reports, highlighting the biological significance and potential mechanisms of the observed bioactivities. Through this structured, stepwise approach to self-directed learning, students become familiar with bioactivity screening techniques for natural products and develop the ability to translate experimental findings into coherent scientific narratives.
學習評量方式
Attendance: 10%
Midterm assessment (exam or experimental assignments): 30%
Progress presentation (experimental progress and preliminary results): 30%
Final written report: 30%
教科書＆參考書目(書名、作者、書局、代理商、說明)
Meneely, P. M., Dahlberg, C. L., & Rose, J. K. (2019). Working with Worms: Caenorhabditis elegans as a Model Organism. Current Protocols Essential Laboratory Techniques, 19, e35. doi: 10.1002/cpet.35
Strange, Kevin, and SpringerLink. C. elegans Methods and Applications / Edited by Kevin Strange. Totowa, NJ: Humana Press, 2006. Web.
課程教材（教師個人網址請列在本校內之網址）
Lecture slides and selected research articles.
課程輔導時間
After class
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更新日期 西元年/月/日：2026/08/20 22:57:32 列印日期 西元年/月/日：2026 / 8 / 25
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