NCHU Course Outline
Course Name (中) 抗癌藥物機制導論(6607)
(Eng.) Introduction to The Mechanisms of Anticancer Drugs
Offering Dept Graduate Institute of Biomedical Sciences
Course Type Elective Credits 2 Teacher 張嘉哲
Department Graduate Institute of Biomedical Sciences / Graduate Language Chinese 英文/EMI Semester 2025-FALL
Course Description
本課程旨在介紹抗癌物質(包括小分子、天然物、中藥單離成份等等)之抗癌效應背後的分子毒理/藥理機制,並介紹如何利用這些機制開發新的癌症治療方法。
Prerequisites
self-directed learning in the course Y
Relevance of Course Objectives and Core Learning Outcomes(%) Teaching and Assessment Methods for Course Objectives
Course Objectives Competency Indicators Ratio(%) Teaching Methods Assessment Methods
培育具獨立思考、創新與研究能力之生醫專業人才.提供從事生物醫學領域研究的知識與技能
Discussion
Lecturing
Written Presentation
Oral Presentation
Course Content and Homework/Schedule/Tests Schedule
Week Course Content
Week 1 1. Traditional therapy and Targeted therapy against cancer
Week 2 2. Drug and Drug targets
Week 3 3. Oncogenes (e.g. Ras, Src) as anticancer drug targets
Week 4 4. Tumor suppressor genes (e.g. p53) as anticancer drug targets
Week 5 5. Drugs targeting cell cycle progression (e.g. CDK inhibitors)
Week 6 6. Drugs targeting DNA and DNA metabolism
Week 7 7. Drugs targeting microtubule dynamics
Week 8 8. Drugs targeting cancer cell metabolism
Week 9 9. Drugs targeting cell death programs
Week 10 10. Drugs targeting angiogenesis
Week 11 11. Drugs targeting metastasis
Week 12 12. Drugs targeting immortality
Week 13 13. Drugs targeting protein stability
Week 14 14. Drugs targeting cancer stem cells
Week 15 15. Immunotherapy drugs
Week 16 6. Drug resistance 討論 報告
self-directed
learning

Evaluation
出席率(Attendance):20%
課堂討論(Participation in Discussion):40%
課後作業(Assignment):40%
Textbook & other References
1. 自編教材
2. 參考書目:Patrick, G.L. (2013) An Introduction to Medicinal Chemistry 2nd edition, published by Oxford University Press
Teaching Aids & Teacher's Website
1. 自編教材
2. 參考書目:Patrick, G.L. (2013) An Introduction to Medicinal Chemistry 2nd edition, published by Oxford University Press
Office Hours
星期三 15:00~17:00
Sustainable Development Goals, SDGs(Link URL)
 include experience courses:N
Please respect the intellectual property rights and use the materials legally.Please respect gender equality.
Update Date, year/month/day:None Printed Date, year/month/day:2025 / 9 / 01
The second-hand book website:http://www.myub.com.tw/