| 週次 |
授課內容 |
| 第1週 |
Introduction |
| 第2週 |
Overview |
| 第3週 |
Nutrient-Genome Interactions in 1C metabolism in Human Health. Case Study: Regulation of Folate-Mediated One-Carbon Metabolism by Methylenetetrahydrofolate Reductase (MTHFR). |
| 第4週 |
Nutrient-Genome Interactions in 1C metabolism in Human Health. Case Study: Regulation of Folate-Mediated One-Carbon Metabolism by Glycine N-Methyltransferase (GNMT) |
| 第5週 |
Drug-Genome Interactions in 1C metabolism. Case Study: Drug and gene interactions. Case Study: Regulation of Folate-Mediated One-Carbon Metabolism by DMARDs
Term paper and homework discussions 1 |
| 第6週 |
Drug impacts on 1C metabolism. Case Study: Regulation of Folate-Mediated One-Carbon Metabolism by Biologics (Jaki, anti-TNF, anti-IL6)
Term paper and homework discussions 2 |
| 第7週 |
Partitioning in 1C Metabolism and Their Interactions with Cofactors. Case Study: non-nutritive sweeteners
Enzymes in 1C Metabolism & Their Interactions with Cofactors. Term paper and homework discussions 3 |
| 第8週 |
Partitioning in 1C Metabolism and Their Interactions with Cofactors. Case Study: Regulation of aerobic exercise and endurance resistant training on 1C metabolism
Term paper and homework discussions 4 |
| 第9週 |
Partitioning in 1C Metabolism and Their Interactions with Cofactors. Case Study: Regulation of prebiotics probiotics and postbiotics on 1C metabolism
Term paper and homework discussions 5 |
| 第10週 |
Folate and Folic Acid in Cancer. Case Study: GNMT I, II, III, and what’s next?
Term paper and homework discussions 6 |
| 第11週 |
Dietary factors that affect 1C Metabolism, and the gene-nutrient interactions. Tracing Metabolic Fate of Mitochondrial Glycine Cleavage System Derived Formate In Vitro and In Vivo. Factors affect 1C Metabolism-Energy Expenditure (ketogenic diet, intermittent fasting and caloric restriction)
Term paper and homework discussions 7 |
| 第12週 |
1C Metabolism in Human Diseases. Lecture: Statistical Analyses for Human Study Design (case control, RCT). Case Study: AJM, JN, Gut, CCR, WJG
Term paper and homework discussions 8 |
| 第13週 |
1C Metabolism in Human Diseases. Case Study: Vitamin B6 metabolism during inflammation
Term paper and homework discussions 9
|
| 第14週 |
1C Metabolism in Human Diseases. Lecture and case Study:1C in inflammation
Term paper and homework discussions 10 |
| 第15週 |
1C Metabolism in Human Diseases. Lecture and case Study: diabetes and anti diabetic medications
Term paper and homework discussions 11 |
| 第16週 |
1C Metabolism in Human Diseases. Lecture and case Study: One-Carbon Metabolism during aging
Term paper and homework discussions 12 |
| 第17週 |
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| 第18週 |
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