| 週次 |
授課內容 |
| 第1週 |
1.The Process of Metastasis
(1)The main steps in the formation of a metastasis
(2)Sequential Steps in The Pathogenesis of Cancer Metastasis |
| 第2週 |
2.Dissemination of tumor cells:Mechanisms of tumor metastasis/invasion
(1)Mechanical pressure
(2)Release of lytic enzymes
(3)Increase motility of individual cells |
| 第3週 |
3.Preferential sites of metastasis
(1)Mechanistic theory :first-pass organ
(2)Seed and soil: need a proper environment for lodgment |
| 第4週 |
4.Genetic heterogeneity of micrometastases |
| 第5週 |
5.Model of the evolution of colonizing ability for micrometastasis |
| 第6週 |
6.Molecules involved in metastasis
(1)Multi-step process of metastasis
(2)The steps that adhesion molecules might be involved in
A. Invasion of metastatic cells
B. Extravasation of metastatic cells |
| 第7週 |
6.Molecules involved in metastasis
(1)Multi-step process of metastasis
(2)The steps that adhesion molecules might be involved in
A. Invasion of metastatic cells
B. Extravasation of metastatic cells |
| 第8週 |
7.The processes of metastasis involved
(1)Cell-Cell adhesion and interaction Breaking of homotypic recognition and changes in heterotypic recognition
Effects of macrophages on invasion and metastasis
(2)Cell-Matrix adhesion and interaction Adhesive Recognition Sequences
The Integrin Receptor Family Model of signal transduction in Cell-ECM interactions Migration
(3)Neoangiogenesis and lymphangiogenesis |
| 第9週 |
7.The processes of metastasis involved
(1)Cell-Cell adhesion and interaction Breaking of homotypic recognition and changes in heterotypic recognition
Effects of macrophages on invasion and metastasis
(2)Cell-Matrix adhesion and interaction Adhesive Recognition Sequences
The Integrin Receptor Family Model of signal transduction in Cell-ECM interactions Migration
(3)Neoangiogenesis and lymphangiogenesis |
| 第10週 |
7.The processes of metastasis involved
(1)Cell-Cell adhesion and interaction Breaking of homotypic recognition and changes in heterotypic recognition
Effects of macrophages on invasion and metastasis
(2)Cell-Matrix adhesion and interaction Adhesive Recognition Sequences
The Integrin Receptor Family Model of signal transduction in Cell-ECM interactions Migration
(3)Neoangiogenesis and lymphangiogenesis |
| 第11週 |
8.Proteases involved in metastatic spread
(1)Metalloproteinases
(2)Serine proteases
(3)Cysteine proteases |
| 第12週 |
8.Proteases involved in metastatic spread
(1)Metalloproteinases
(2)Serine proteases
(3)Cysteine proteases |
| 第13週 |
9.The cycle of epithelial-cell plasticity |
| 第14週 |
10.Basic cellular and molecular processes governing the epithelial–mesenchymal transition (EMT) |
| 第15週 |
11.Cellular changes associated with EMT |
| 第16週 |
2.The EMT regulatory networkϵ.The model of metastasis involving EMT and MET϶.Stromal signals may trigger EMT program |
自主學習
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