國立中興大學教學大綱

課程名稱	(中) 抗病毒藥物的理論與應用(7282)
	(Eng.) Antiviral Drug: Theory and Application
開課單位	獸病所
課程類別	選修			學分	2	授課教師	吳弘毅
選課單位	獸病所 / 碩士班			授課使用語言	中文	英文/EMI		開課學期	1141
課程簡述	The first part of the course is to understand how virus finishes its life cycle in the host. The topics of second part focus on the mechanisms of antiviral drugs. The third part of the course is to introduce the development and application of current antiviral drugs. Topics of current interest in the field are selected and reviewed by the student. Presentations are followed by a general informal discussion. Under certain circumstances, reports of presentation may be made by students.
先修課程名稱								課程含自主學習	Y

課程與核心能力關聯配比(%)			課程目標之教學方法與評量方法
課程目標	核心能力	配比(%)	教學方法	評量方法
1. To understand the replication cycle of virus and how virus finish its life cycle by using host factors. 2. To explore how antiviral is developed and how antivirals work on viruses.	1.應用動物醫學、病理學及生物醫學專業知能 3.病理生物醫學訓練、致病機理研究及生技研發技術等關鍵能力的培養	70 30	講授	測驗 書面報告
授課內容(單元名稱與內容、習作/每週授課、考試進度-共16週加自主學習)
週次 授課內容 第1週 Overview of DNA virus life cycle 第2週 Overview of RNA virus life cycle 第3週 Overview of antiviral drug discovery and development I 第4週 Overview of antiviral drug discovery and development II 第5週 Antiviral drug targets I 第6週 Antiviral drug targets II 第7週 Strategies to design antiviral drugs I 第8週 Strategies to design antiviral drugs II 第9週 Perspectives for the therapy against viruses 第10週 Viral invasion of the interferon system: novel targets for drug discovery I 第11週 Viral invasion of the interferon system: novel targets for drug discovery II 第12週 Structural biology of flaviviral replication and opportunities for drug design 第13週 West nile virus: new targets for potential antiviral drugs 第14週 Antiviral strategies for Ebola virus 第15週 S-adenosylhomocysteine hydrolase inhibitors as a source of anti-filovirus agents 第16週 IMPDH inhibitors: Discovery of antiviral agents against emerging diseases Lethal mutagenesis: exploiting error-prone replication of riboviral therapy Oral presentation 自主學習 內容
學習評量方式
Examination, Power point presentation, and writing assignment
教科書＆參考書目(書名、作者、書局、代理商、說明)
1. Advances in antiviral drug design, E. de Clercq, Elsevier, 2007 2. Antiviral Drugs: From Basic Discovery Through Clinical Trials, Wieslaw M. Kazmierski, Wiley, 2011
課程教材（教師個人網址請列在本校內之網址）
https://web2-sso.nchu.edu.tw/pweb/index2.php?pid=530
課程輔導時間
Wednesday 11:00-12:00
聯合國全球永續發展目標(連結網址)
提供體驗課程：N

請尊重智慧財產權及性別平等意識，不得非法影印他人著作。
更新日期 西元年/月/日：無	列印日期 西元年/月/日：2025 / 9 / 01
MyTB教科書訂購平台：http://www.mytb.com.tw/