國立中興大學教學大綱

課程名稱	(中) 膜蛋白功能與結構(7315)
	(Eng.) Functional and Structural Studies of Membrane Proteins
開課單位	生化所
課程類別	選修			學分	3	授課教師	胡念仁
選課單位	生化所 / 碩士班			授課使用語言	英文	開課學期	1142
課程簡述	The cell membrane forms a hydrophobic barrier on the cell surface to maintain a constant concentration of biochemical substances within the cytoplasm. However, when a cell communicates with its environment or exchanges substances, it requires membrane proteins to assist water-soluble small molecules in penetrating this barrier. Consequently, membrane proteins play crucial roles in cellular physiology, nutrient exchange, signal transduction, and the immune system. Human genome sequencing predicts that 30% of genes are transcribed into membrane proteins. For a long time, membrane proteins have been regarded as vital drug targets by pharmaceutical companies; currently, 50% of commercially available drugs are designed and developed to target membrane proteins. Therefore, understanding the function and structure of membrane proteins is essential for comprehending many fundamental questions in cellular physiology. This course will provide an in-depth exploration of the physiological functions, structural classifications, and biochemical instrumentation used for membrane proteins, as well as their future applications in pharmacology and clinical practice.
先修課程名稱

課程與核心能力關聯配比(%)			課程目標之教學方法與評量方法
課程目標	核心能力	配比(%)	教學方法	評量方法
To enable students to understand the functions of membrane proteins from the perspective of their molecular 3D structures, and to apply this information to drug development and clinical diagnostics.			專題探討/製作 討論 講授	口頭報告
授課內容(單元名稱與內容、習作/每週授課、考試進度-共16週加自主學習)
週次 授課內容 第1週 Classification of membrane proteins 第2週 Membrane protein folding and insertion 第3週 Photoreaction center 第4週 Electron transport complex 第5週 Channels 第6週 Transporters 第7週 Receptors, G protein couple receptor (GPCR) 第8週 Mid-term exam 第9週 Porin 第10週 Membrane enzymes 第11週 Pore-forming toxins 第12週 Expression and purification of integral membrane protein 第13週 Crystallization of integral membrane proteins 第14週 Functional studies of membrane proteins 第15週 Structural studies of membrane proteins, Pharmaceutical applications 第16週 Final oral presentation 自主學習 內容    03.製作專題報告
學習評量方式
每週quiz問答 期中個人報告 期末小組報告
教科書＆參考書目(書名、作者、書局、代理商、說明)
Biophysical Analysis of Membrane Proteins: Investigating Structure and Function, Eva Pebay-Peyroula Membrane Structural Biology: With Biochemical and Biophysical Foundations, Mary Luckey Journal publications in Nature, Science, Nature Structural & Molecular Biology, EMBO, PNAS, Nature Protocol, Nature Methods, etc.
課程教材（教師個人網址請列在本校內之網址）
Biophysical Analysis of Membrane Proteins: Investigating Structure and Function, Eva Pebay-Peyroula Membrane Structural Biology: With Biochemical and Biophysical Foundations, Mary Luckey Journal publications in Nature, Science, Nature Structural & Molecular Biology, EMBO, PNAS, Nature Protocol, Nature Methods, etc.
課程輔導時間
Every Tuesday 9:00-12:00 AM.
聯合國全球永續發展目標(連結網址)
04.教育品質 提供體驗課程：N

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