| 週次 |
授課內容 |
| 第1週 |
脂質生化結構以及生物功能介紹
- Overview of lipid classes and functions
- Structure and function of phosphoinositides
|
| 第2週 |
磷酸肌醇介紹
- Enzymes involved in phosphoinositide synthesis
- Pathways for the production of different phosphoinositides
|
| 第3週 |
磷酸肌醇分佈與位置
- Cellular compartments and phosphoinositide distribution
- Techniques for visualizing phosphoinositide dynamics
|
| 第4週 |
磷酸肌醇身份轉換
- Phosphoinositide kinases and phosphatases
- Regulation of phosphoinositide turnover
|
| 第5週 |
磷酸肌醇在生物膜結構以及動態功能
- Phosphoinositides in membrane trafficking
- Vesicular transport and membrane curvature
|
| 第6週 |
磷脂肌醇3激酶（PI3K）的訊息傳遞
- Mechanisms of PI3K/AKT signaling
- Mechanisms of class II, class III PI3K in membrane trafficking
- Biological functions and implications in health
|
| 第7週 |
磷脂肌醇3激酶的藥物設計
- Strategies of PI3K drug development: From pan- to isoform-selective inhibitors
- Applications of PI3K inhibitors
|
| 第8週 |
期中書面報告 |
| 第9週 |
磷酸肌醇與細胞內能量調節
- Phosphoinositide conversion in lysosome function
- Phosphoinositide conversion in autophagy
|
| 第10週 |
磷酸肌醇在細胞骨架的動態功能
- Regulation of the cytoskeleton by phosphoinositides
- Implications for cell shape and motility
|
| 第11週 |
磷酸肌醇在神經囊泡運輸的功能
- Structure of neuron
- Phosphoinositide conversion in neuron function
|
| 第12週 |
磷酸肌醇在感染性疾病的機制
- How bacteria and viruses hijack phosphoinositide conversion
|
| 第13週 |
磷酸肌醇與基因遺傳疾病
- Genetic disorders and cancer associated with phosphoinositides
- Therapeutic strategies targeting phosphoinositide pathways
|
| 第14週 |
實驗室偵測磷酸肌醇生合成的生化技術
- Methods for analyzing phosphoinositide synthesis in vitro
- Emerging tools and technologies for phosphoinositide research in vitro
|
| 第15週 |
實驗室偵測磷酸肌醇的細胞生物學技術
- Methods for analyzing phosphoinositide dynamics in the cell
- Emerging tools and technologies in phosphoinositide research in the cell
|
| 第16週 |
書報討論：磷酸肌醇相關研究的目前趨勢與未來方向
- Recent advances in phosphoinositide biology
- Future research directions and potential therapy
|
自主學習
內容 |
03.製作專題報告
|