NCHU Course Outline
Course Name (中) 環境毒理學(6788)
(Eng.) Environmental Toxicology
Offering Dept Department of Environmental Engineering
Course Type Elective Credits 3 Teacher LIN,PO-HSIUNG
Department Department of Environmental Engineering / Graduate Language English Semester 2026-FALL
Course Description To study the basic principle of toxicology and to explore the mechanisms by which environmental toxicants exert their effects in mammals.
Prerequisites
Relevance of Course Objectives and Core Learning Outcomes(%) Teaching and Assessment Methods for Course Objectives
Course Objectives Competency Indicators Ratio(%) Teaching Methods Assessment Methods
Study the basic principles of toxicology and focus on the characteristics of environmental pollutants in relation to the underlying mechanisms by which harmful toxic substances exert their toxic action on living organisms .研習毒理學之基本原理，並針對環境污染物之特性，個別深入探討環境中有害毒性物質其致毒機轉。
1.Expertise in environmental engineering.
2.Ability to plan and execute research on environmental engineering topics.
3.Ability to write professional papers in environmental engineering.
4.Innovative thinking and independent problem-solving skills.
5.Ability to coordinate and integrate with people from different fields
6.Good international outlook.
7.Ability to lead, manage and plan.
8.Ability to grow through lifelong self-learning.
15
15
35
10
5
10
5
5
Discussion
Networking / Distance Education
Lecturing
Assignment
Attendance
Written Presentation
Quiz
Course Content and Homework/Schedule/Tests Schedule
Week Course Content
Week 1 週次(week) 單元名稱與內容(subject and content)
01 毒理學簡介流行病學及毒理學測試研究 Lecture 1-Introduction to Toxicology, Epidemiological Studies, Toxicological Studies
Week 2 02 曝露路徑及劑量效應研究 Lecture 2-Introduction to Routes of Exposure; The Dose-Response Relationship
Week 3 03 分子生物學簡介 Lecture 3- Introduction to Molecular and Cell Biology
Week 4 04 人體生理學簡介 Lecture 4- Introduction to Human Physiology
Week 5 05 毒理動力學Lecture 5 –Toxicokinetics (I): Absorption, Distribution, Metabolism, and Elimination of Toxics
Week 6 06 毒理動力學 Lecture 6 - Toxicokinetics (II): Metabolic Bioactivation: Microsomal Cytochrome P450s and Phase II Enzymes
Week 7 07 曝露路徑及劑量與效應相關性特論 Lecture 7- Special topics in Routes of Exposure and The Dose-Response Relationship
Week 8 08 毒理效應學-標的器官效應 Lectrue 8-Toxicodynamics-Target Organ Effects
Week 9 09 期中考 Midterm Exam
Week 10 10 (I)毒性效應學-基因突變 Lecture 9- Toxicodynamics-Mutagenesis
Week 11 11 (II)毒性效應學-致畸作用Lecture 9- Toxicodynamics-Teratogenesis
Week 12 12 (III)毒性效應學-致癌作用Lecture 9- Toxicodynamics- Carcinogenesis
Week 13 13 毒性物質之簡介 (I) 室內與室外空氣污染物石油蒸餾物金屬及農藥 Lecture 10-Survey of Toxic Substances (I): Outdoor air pollutants; Indoor air pollutants; Petroleum distillates; Metals ; Pesticides.
Week 14 14 毒性物質之簡介(II)多環芳香族碳氫化物及鹵族芳香族化物Lecture 11-Survey of Toxic Substances (II): polycyclic aromatic hydrocarbons (PAHs) and halogenated aromatic hydrocarbons (including dioxins PCBs and pentachlorophenol)
Week 15 15 毒性物質之簡介 (III) 鄰苯二甲酸酯以及藥物及個人衛生保健品Lecture 12-Survey of Toxic Substances (III): Phthalates and other pharmaceutical personal care products (PPCPs) or emergent contaminants
Week 16 6 期末考 Final Exam
self-directed
learning		    03.Preparing presentations or reports related to industry and academia.
Evaluation
mid-term and final examination plus term papers (作業)
Textbook & other References
1. Basic Toxicology, Frank C. Lu. Four edition, 2002.
2. Casarett and Doull’s Toxicology, Amdur et al. 2018.
Teaching Aids & Teacher's Website
Journal articles
Office Hours
To be arranged 依本系所規定的輔導時間
Please respect the intellectual property rights and use the materials and protected electronic files legally. Please respect gender equality.
Update Date, year/month/day：None Printed Date, year/month/day：2026 / 8 / 24
The second-hand book website：http://www.myub.com.tw/