國立中興大學教學大綱
課程名稱 (中) 天然物生物活性研究(6945)
(Eng.) Bioactivity Research of Natural Products
開課單位 代謝碩士學程
課程類別 選修 學分 3 授課教師 顏佩翎
選課單位 代謝碩士學程 / 碩士班 授課使用語言 中/英文 開課學期 1142
課程簡述 This course introduces the use of model organisms in the evaluation of biological activity of natural products. The course emphasizes experimental design, phenotypic assays, and molecular endpoints relevant to oxidative stress, aging, neurodegeneration, and metabolism. Students will learn how to utilize model organisms for in vivo screening, pathway analysis, and translational research through hands-on case studies, literature discussion, and project presentations.
先修課程名稱
課程與核心能力關聯配比(%) 課程目標之教學方法與評量方法
課程目標 核心能力 配比(%) 教學方法 評量方法
Students will be able to:
1. Describe the characteristics and advantages of model organisms.
2. Interpret biological effects and molecular mechanisms of natural compounds.
討論
講授
書面報告
口頭報告
作業
授課內容(單元名稱與內容、習作/每週授課、考試進度-共16週加自主學習)
週次 授課內容
第1週 Introduction to Natural Product Bioactivity and Model Systems
第2週 Life Cycle, Handling, and Maintenance of Model Organisms
第3週 Aging and Longevity Assays in Bioactivity Evaluation
第4週 Stress Response Pathways: Oxidative, Heat, ER Stress
第5週 Assessing Metabolic Health
第6週 Neurobehavioral Assays and Neurotoxicity Screening
第7週 Natural Products and Immune Modulation
第8週 Mid-term: Experimental Design Proposal
第9週 Genetic and Molecular Tools for Functional Analysis
第10週 Molecular Pathways Targeted by Natural Compounds I
第11週 Molecular Pathways Targeted by Natural Compounds II
第12週 Omics Platforms for Natural Product Research I
第13週 Omics Platforms for Natural Product Research II
第14週 Experimental Design, Reproducibility, and Data Interpretation
第15週 Applications for Functional Food and Preventive Health
第16週 Student Presentations
自主學習
內容		    03.製作專題報告
The final project of this course promotes student learning through self-directed research proposal development, requiring students to independently select a natural product or extract, conduct literature analysis, and integrate bioactivity evaluation with experimental design.
學習評量方式
Midterm assessment (exam or written assignments): 30%
Case study presentation: 40%
Final written report: 30%.
教科書＆參考書目(書名、作者、書局、代理商、說明)
Atta-ur-Rahman (Ed.). Studies in Natural Products Chemistry (Book series). Elsevier.
WormBook: The Online Review of C. elegans Biology. http://www.wormbook.org
課程教材（教師個人網址請列在本校內之網址）
Lecture slides and selected research articles.
課程輔導時間
After class
聯合國全球永續發展目標(連結網址)
03.健康與福祉提供體驗課程：N
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更新日期 西元年/月/日：2026/02/06 12:44:02 列印日期 西元年/月/日：2026 / 3 / 15
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